ID   Y146_MYCTU              Reviewed;         310 AA.
AC   P9WFJ3; L0T5V3; P96823; Q7DAE0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0146;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv0146;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP42871.1; -; Genomic_DNA.
DR   PIR; E70617; E70617.
DR   RefSeq; NP_214660.1; NC_000962.3.
DR   RefSeq; WP_003900814.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WFJ3; -.
DR   SMR; P9WFJ3; -.
DR   STRING; 83332.Rv0146; -.
DR   PaxDb; P9WFJ3; -.
DR   DNASU; 886849; -.
DR   GeneID; 45424112; -.
DR   GeneID; 886849; -.
DR   KEGG; mtu:Rv0146; -.
DR   PATRIC; fig|83332.111.peg.168; -.
DR   TubercuList; Rv0146; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; PMDITEL; -.
DR   PhylomeDB; P9WFJ3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0052559; P:induction by symbiont of host immune response; IDA:MTBBASE.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..310
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Rv0146"
FT                   /id="PRO_0000361236"
FT   BINDING         132
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         161..162
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  34016 MW;  1B27617869F6059E CRC64;
     MRTHDDTWDI KTSVGATAVM VAAARAVETD RPDPLIRDPY ARLLVTNAGA GAIWEAMLDP
     TLVAKAAAID AETAAIVAYL RSYQAVRTNF FDTYFASAVA AGIRQVVILA SGLDSRAYRL
     DWPAGTIVYE IDQPKVLSYK STTLAENGVT PSAGRREVPA DLRQDWPAAL RDAGFDPTAR
     TAWLAEGLLM YLPAEAQDRL FTQVGAVSVA GSRIAAETAP VHGEERRAEM RARFKKVADV
     LGIEQTIDVQ ELVYHDQDRA SVADWLTDHG WRARSQRAPD EMRRVGRWVE GVPMADDPTA
     FAEFVTAERL