ID   Y1479_MYCS2             Reviewed;         303 AA.
AC   A0QSH3; I7G440;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MSMEG_1479/MSMEI_1443;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MSMEG_1479, MSMEI_1443;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000480; ABK72485.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP37916.1; -; Genomic_DNA.
DR   RefSeq; WP_003892866.1; NZ_SIJM01000016.1.
DR   RefSeq; YP_885861.1; NC_008596.1.
DR   AlphaFoldDB; A0QSH3; -.
DR   SMR; A0QSH3; -.
DR   STRING; 246196.MSMEI_1443; -.
DR   EnsemblBacteria; ABK72485; ABK72485; MSMEG_1479.
DR   EnsemblBacteria; AFP37916; AFP37916; MSMEI_1443.
DR   GeneID; 66732936; -.
DR   KEGG; msg:MSMEI_1443; -.
DR   KEGG; msm:MSMEG_1479; -.
DR   PATRIC; fig|246196.19.peg.1464; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; FFIKMMD; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..303
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MSMEG_1479/MSMEI_1443"
FT                   /id="PRO_0000361195"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..160
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  32948 MW;  BC9D7D5F1FAF1CA2 CRC64;
     MVRSDNDTWD LASSVGATAT MVAAGRAVVS QDPGGLINDP FAAPLVRAVG IEALTMLADG
     KFDIEKVLPE SAARVRANID EMAVRTKFFD DYFMDATGRG VGQAVILASG LDSRAYRLPW
     PDGTVVYEID QPDVIEFKTR TLADLGAEPT CERRTVSIDL RDDWPAALRA AGFDPSAPTA
     WCAEGLLIYL PPEAQDKLFD DIHHLSAPGS TVATEFVPAL KDFDPEKARQ ATETLTRMGV
     DIDMPSLIYH GERHSASDYL ETKGWQMDSA ARATLFTRYG LPAPGHDDDD PLGEIIYISG
     TLR