ID   Y1480_MYCS2             Reviewed;         298 AA.
AC   A0QSH4; I7FYA3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MSMEG_1480/MSMEI_1444;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MSMEG_1480, MSMEI_1444;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000480; ABK71545.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP37917.1; -; Genomic_DNA.
DR   RefSeq; WP_003892867.1; NZ_SIJM01000016.1.
DR   RefSeq; YP_885862.1; NC_008596.1.
DR   AlphaFoldDB; A0QSH4; -.
DR   SMR; A0QSH4; -.
DR   STRING; 246196.MSMEI_1444; -.
DR   EnsemblBacteria; ABK71545; ABK71545; MSMEG_1480.
DR   EnsemblBacteria; AFP37917; AFP37917; MSMEI_1444.
DR   GeneID; 66732937; -.
DR   KEGG; msg:MSMEI_1444; -.
DR   KEGG; msm:MSMEG_1480; -.
DR   PATRIC; fig|246196.19.peg.1465; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; GMASRTW; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..298
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MSMEG_1480/MSMEI_1444"
FT                   /id="PRO_0000361196"
FT   BINDING         127
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         156..157
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   298 AA;  32377 MW;  E3DCEA9BCD2AF129 CRC64;
     MTRTDGDTWD LATSVGSTAT GVAAMRALAT RQPDPLIDDP YADALVKAVG LEHCIALADG
     ETCVEGDPML DLNRMCEQIA VRTRYFDELF IAAGADGVRQ AVILASGLDT RAYRLDWPAG
     TVVFEVDQPQ VIEFKTRTLA DLGAQPTAER RTVAVDLRDD WPAALRDAGF DPAEPTAWIA
     EGLLIYLPAE AQDRLLDNIT ALSAPGSRLA TEHMDHRILA EGAGKRIGEW SRRVGSSLDI
     ADLFYTGERN TAGDYLRGLG WQVTVRPSKE AYADHGFELP EEMAELSGDS GYLSAHLK