ID   Y1481_MYCS2             Reviewed;         304 AA.
AC   A0QSH5; I7FGE8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MSMEG_1481/MSMEI_1445;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MSMEG_1481, MSMEI_1445;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000480; ABK73326.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP37918.1; -; Genomic_DNA.
DR   RefSeq; WP_003892868.1; NZ_SIJM01000016.1.
DR   RefSeq; YP_885863.1; NC_008596.1.
DR   AlphaFoldDB; A0QSH5; -.
DR   SMR; A0QSH5; -.
DR   STRING; 246196.MSMEI_1445; -.
DR   EnsemblBacteria; ABK73326; ABK73326; MSMEG_1481.
DR   EnsemblBacteria; AFP37918; AFP37918; MSMEI_1445.
DR   GeneID; 66732938; -.
DR   KEGG; msg:MSMEI_1445; -.
DR   KEGG; msm:MSMEG_1481; -.
DR   PATRIC; fig|246196.19.peg.1466; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; QDSWDLA; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..304
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MSMEG_1481/MSMEI_1445"
FT                   /id="PRO_0000361197"
FT   BINDING         127
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         156..157
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   304 AA;  32703 MW;  A4FA750A7DB13B54 CRC64;
     MARTDTDSWD LASSVGATAT MVAAARAIAS TEPNALIDDP YAADLVRKVG LEFFTKLVDG
     DIALDGDDAA AAGLMVSMMA VRTRFFDDFF CDAAGAGIRQ SVILAAGLDS RAYRLGWPAG
     TVVYEIDQPR VIEAKTAAMA EIGASPTAER RTVAVDLRDD WPAALRAAGF DAATPTAWIA
     EGLLVYLPPE AQDRLFDNIT ALSARGSRLA TEYHPDITST LRGRGQAMSE RWRDHGFDVD
     LSDLWYGGDR NAADEYLAGH GWQVSTRPRP EVFAAYGRTF PDLTLTGDDN AAMRQSVAIT
     ATRS