ID   Y1482_MYCS2             Reviewed;         304 AA.
AC   A0QSH6; I7G5Q9;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MSMEG_1482/MSMEI_1446;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MSMEG_1482, MSMEI_1446;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000480; ABK70915.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP37919.1; -; Genomic_DNA.
DR   RefSeq; WP_003892869.1; NZ_SIJM01000016.1.
DR   RefSeq; YP_885864.1; NC_008596.1.
DR   AlphaFoldDB; A0QSH6; -.
DR   SMR; A0QSH6; -.
DR   STRING; 246196.MSMEI_1446; -.
DR   EnsemblBacteria; ABK70915; ABK70915; MSMEG_1482.
DR   EnsemblBacteria; AFP37919; AFP37919; MSMEI_1446.
DR   GeneID; 66732939; -.
DR   KEGG; msg:MSMEI_1446; -.
DR   KEGG; msm:MSMEG_1482; -.
DR   PATRIC; fig|246196.19.peg.1467; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; DFFTRWV; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..304
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MSMEG_1482/MSMEI_1446"
FT                   /id="PRO_0000361198"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..160
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   304 AA;  33122 MW;  74C11DFBD6FB5AC9 CRC64;
     MARTENDTWD LASSVGATAT MVAAARALAT NADEPAIDDP FAAPLVRAVG VDFFTKLVDD
     NFDLTALDPE AAEGLTRFAN GMAARTRFFD DFFLDAARAG VRQFVILASG LDARAYRLPW
     PAGSVVFEID QPDVIEFKTK ALADLGALPT TDRRAVAVDL RFDWPAALTE AGFDPAEPTA
     WIAEGLLGYL PPEAQDRLLD QIAELSAPGS RVAVEEIPAI EEEDHEEIAA RMKDFSDRWR
     AHGFDLDFTE LVFLGDRADV SSYLQGHGWK TTSMTSDELL VHNGLPRVDD DAQIGSVVYV
     TATR