ID   Y1487_METJA             Reviewed;         426 AA.
AC   Q58882;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Uncharacterized methyltransferase MJ1487;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MJ1487;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L77117; AAB99497.1; -; Genomic_DNA.
DR   PIR; F64485; F64485.
DR   RefSeq; WP_010871009.1; NC_000909.1.
DR   AlphaFoldDB; Q58882; -.
DR   SMR; Q58882; -.
DR   STRING; 243232.MJ_1487; -.
DR   EnsemblBacteria; AAB99497; AAB99497; MJ_1487.
DR   GeneID; 1452393; -.
DR   KEGG; mja:MJ_1487; -.
DR   eggNOG; arCOG01356; Archaea.
DR   HOGENOM; CLU_042889_0_0_2; -.
DR   InParanoid; Q58882; -.
DR   OMA; AHYFMPL; -.
DR   OrthoDB; 90547at2157; -.
DR   PhylomeDB; Q58882; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.30.20; -; 1.
DR   InterPro; IPR023980; CHP04013_B12-bd/rSAM.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR04013; B12_SAM_MJ_1487; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..426
FT                   /note="Uncharacterized methyltransferase MJ1487"
FT                   /id="PRO_0000107371"
FT   DOMAIN          1..137
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00666"
FT   DOMAIN          169..409
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   BINDING         183
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         187
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         190
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   426 AA;  48962 MW;  44C59FD3C9397351 CRC64;
     MEENTALVVY YTKLHKNSFN ALIGALEIDE YFDNLPIYFA NKKDIFNLKE VLKKYDKVVI
     AISFFTTELW KTYELINELK AKYQSYRNKI IYLAGGPHPT GDPKGTLKLG FDVVCIGEGE
     ETFPEFIKAV NEDEDYKKVK GIAYLNDNEF IYTGRRKPVD LNKYPPFPVK HNKFGHIEIT
     RGCPYKCYFC QTPRIFGKKI RHRDVENIYK YVEIMAERNL KDIRFITPNA FGYGSKDGKT
     LNIDKIEKLL ESIREILGNN GRIFFGTFPS EVRPEHVNIE TVDLILRYAD NKNLVIGAQS
     GSEKVLELCH RGHTVEDVYN AVRVARKAGL GVDVDFIFGL PGETEEDVEK TIKVMKDLIK
     MGAKIHAHTF MPLPQTPFAK ANPGKVDKKI IRAMRYEIPK GIFHGTWHNQ EIIAQKISKY
     LKTGKL