ID   Y1491_MYCTA             Reviewed;         335 AA.
AC   A5U2I5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=UPF0353 protein MRA_1491 {ECO:0000255|HAMAP-Rule:MF_01340};
GN   OrderedLocusNames=MRA_1491;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01340};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01340}.
CC   -!- SIMILARITY: Belongs to the UPF0353 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01340}.
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DR   EMBL; CP000611; ABQ73235.1; -; Genomic_DNA.
DR   RefSeq; WP_003407530.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U2I5; -.
DR   SMR; A5U2I5; -.
DR   STRING; 419947.MRA_1491; -.
DR   EnsemblBacteria; ABQ73235; ABQ73235; MRA_1491.
DR   GeneID; 45425460; -.
DR   KEGG; mra:MRA_1491; -.
DR   eggNOG; COG2304; Bacteria.
DR   HOGENOM; CLU_024570_2_0_11; -.
DR   OMA; RYFRATD; -.
DR   OrthoDB; 736429at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 1.
DR   HAMAP; MF_01340; UPF0353; 1.
DR   InterPro; IPR022933; UPF0353.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="UPF0353 protein MRA_1491"
FT                   /id="PRO_1000067656"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   DOMAIN          98..294
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
SQ   SEQUENCE   335 AA;  36030 MW;  A8562F98A30DA86C CRC64;
     MTLPLLGPMT LSGFAHSWFF LFLFVVAGLV ALYILMQLAR QRRMLRFANM ELLESVAPKR
     PSRWRHVPAI LLVLSLLLFT IAMAGPTHDV RIPRNRAVVM LVIDVSQSMR ATDVEPSRMV
     AAQEAAKQFA DELTPGINLG LIAYAGTATV LVSPTTNREA TKNALDKLQF ADRTATGEAI
     FTALQAIATV GAVIGGGDTP PPARIVLFSD GKETMPTNPD NPKGAYTAAR TAKDQGVPIS
     TISFGTPYGF VEINDQRQPV PVDDETMKKV AQLSGGNSYN AATLAELRAV YSSLQQQIGY
     ETIKGDASVG WLRLGALALA LAALAALLIN RRLPT