ID   Y1496_MYCTO             Reviewed;         336 AA.
AC   P9WPZ0; L0T711; P63577; P71777;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 2.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Probable GTPase MT1543;
DE            EC=3.6.-.-;
GN   OrderedLocusNames=MT1543;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Probable GTPase. May also bind and hydrolyze ATP. May
CC       function as chaperone (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK45810.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000250|UniProtKB:P9WPZ1};
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DR   EMBL; AE000516; AAK45810.1; ALT_INIT; Genomic_DNA.
DR   PIR; C70712; C70712.
DR   RefSeq; WP_003407596.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WPZ0; -.
DR   SMR; P9WPZ0; -.
DR   EnsemblBacteria; AAK45810; AAK45810; MT1543.
DR   GeneID; 45425476; -.
DR   KEGG; mtc:MT1543; -.
DR   PATRIC; fig|83331.31.peg.1660; -.
DR   HOGENOM; CLU_043725_2_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR005129; GTPase_ArgK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23408; PTHR23408; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00750; lao; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; GTP-binding; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..336
FT                   /note="Probable GTPase MT1543"
FT                   /id="PRO_0000426868"
FT   BINDING         67..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         209
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         245..247
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   336 AA;  36459 MW;  8B4AACF079CE66C7 CRC64;
     MAMMAASHDD DTVDGLATAV RGGDRAALPR AITLVESTRP DHREQAQQLL LRLLPDSGNA
     HRVGITGVPG VGKSTAIEAL GMHLIERGHR VAVLAVDPSS TRTGGSILGD KTRMARLAVH
     PNAYIRPSPT SGTLGGVTRA TRETVVLLEA AGFDVILIET VGVGQSEVAV ANMVDTFVLL
     TLARTGDQLQ GIKKGVLELA DIVVVNKADG EHHKEARLAA RELSAAIRLI YPREALWRPP
     VLTMSAVEGR GLAELWDTVE RHRQVLTGAG EFDARRRDQQ VDWTWQLVRD AVLDRVWSNP
     TVRKVRSELE RRVRAGELTP ALAAQQILEI ANLTDR