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Y1496_MYCTU
ID   Y1496_MYCTU             Reviewed;         336 AA.
AC   P9WPZ1; L0T711; P63577; P71777;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 2.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Probable GTPase Rv1496;
DE            EC=3.6.-.-;
GN   OrderedLocusNames=Rv1496; ORFNames=MTCY277.18;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-21, AND SEQUENCE REVISION TO N-TERMINUS.
RC   STRAIN=H37Rv;
RX   PubMed=34915127; DOI=10.1016/j.ygeno.2021.12.001;
RA   Shi J., Meng S., Wan L., Zhang Z., Jiang S., Zhu H., Dai E., Chang L.,
RA   Gao H., Wan K., Zhang L., Zhao X., Liu H., Lyu Z., Zhang Y., Xu P.;
RT   "Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct
RT   annotated encoding genes.";
RL   Genomics 114:292-304(2022).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) IN COMPLEX WITH GDP, PROBABLE
RP   FUNCTION, AND SUBUNIT.
RG   Seattle structural genomics center for infectious disease (SSGCID);
RT   "Crystal structure of arginine/ornithine transport system ATPase from
RT   Mycobacterium tuberculosis bound to GDP.";
RL   Submitted (APR-2010) to the PDB data bank.
CC   -!- FUNCTION: Probable GTPase. May also bind and hydrolyze ATP. May
CC       function as chaperone (Probable). {ECO:0000305}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|Ref.4}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP44257.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
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DR   EMBL; AL123456; CCP44257.1; ALT_INIT; Genomic_DNA.
DR   PIR; C70712; C70712.
DR   RefSeq; NP_216012.1; NC_000962.3.
DR   RefSeq; WP_003407596.1; NZ_NVQJ01000004.1.
DR   PDB; 3MD0; X-ray; 2.45 A; A=3-336.
DR   PDB; 3P32; X-ray; 1.90 A; A=3-336.
DR   PDB; 4GT1; X-ray; 2.00 A; A=3-336.
DR   PDBsum; 3MD0; -.
DR   PDBsum; 3P32; -.
DR   PDBsum; 4GT1; -.
DR   AlphaFoldDB; P9WPZ1; -.
DR   SMR; P9WPZ1; -.
DR   STRING; 83332.Rv1496; -.
DR   PaxDb; P9WPZ1; -.
DR   DNASU; 886496; -.
DR   GeneID; 45425476; -.
DR   GeneID; 886496; -.
DR   KEGG; mtu:Rv1496; -.
DR   TubercuList; Rv1496; -.
DR   eggNOG; COG1703; Bacteria.
DR   OMA; WMWERID; -.
DR   PhylomeDB; P9WPZ1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR005129; GTPase_ArgK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23408; PTHR23408; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00750; lao; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Chaperone; Direct protein sequencing;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:34915127"
FT   CHAIN           2..336
FT                   /note="Probable GTPase Rv1496"
FT                   /id="PRO_0000157817"
FT   BINDING         67..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   BINDING         209
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   BINDING         245..247
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   HELIX           11..19
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           25..34
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           38..51
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           52..54
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   STRAND          58..64
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           71..83
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   TURN            84..86
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   STRAND          89..94
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           113..116
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   STRAND          121..124
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           132..148
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   STRAND          153..158
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           164..169
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   STRAND          173..182
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   TURN            186..189
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           195..197
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   STRAND          199..204
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           208..210
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           211..228
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   STRAND          239..243
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           244..246
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           250..266
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           269..295
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           298..312
FT                   /evidence="ECO:0007829|PDB:3P32"
FT   HELIX           318..332
FT                   /evidence="ECO:0007829|PDB:3P32"
SQ   SEQUENCE   336 AA;  36459 MW;  8B4AACF079CE66C7 CRC64;
     MAMMAASHDD DTVDGLATAV RGGDRAALPR AITLVESTRP DHREQAQQLL LRLLPDSGNA
     HRVGITGVPG VGKSTAIEAL GMHLIERGHR VAVLAVDPSS TRTGGSILGD KTRMARLAVH
     PNAYIRPSPT SGTLGGVTRA TRETVVLLEA AGFDVILIET VGVGQSEVAV ANMVDTFVLL
     TLARTGDQLQ GIKKGVLELA DIVVVNKADG EHHKEARLAA RELSAAIRLI YPREALWRPP
     VLTMSAVEGR GLAELWDTVE RHRQVLTGAG EFDARRRDQQ VDWTWQLVRD AVLDRVWSNP
     TVRKVRSELE RRVRAGELTP ALAAQQILEI ANLTDR
 
 
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