ID   Y1497_METJA             Reviewed;         346 AA.
AC   Q58892;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Uncharacterized metallohydrolase MJ1497;
DE            EC=3.-.-.-;
GN   OrderedLocusNames=MJ1497;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) or Co(2+) ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M20A family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99508.1; -; Genomic_DNA.
DR   PIR; H64486; H64486.
DR   RefSeq; WP_010871020.1; NC_000909.1.
DR   AlphaFoldDB; Q58892; -.
DR   SMR; Q58892; -.
DR   STRING; 243232.MJ_1497; -.
DR   EnsemblBacteria; AAB99508; AAB99508; MJ_1497.
DR   GeneID; 1452404; -.
DR   KEGG; mja:MJ_1497; -.
DR   eggNOG; arCOG01107; Archaea.
DR   HOGENOM; CLU_800794_0_0_2; -.
DR   InParanoid; Q58892; -.
DR   OMA; VSGHKGM; -.
DR   OrthoDB; 87784at2157; -.
DR   PhylomeDB; Q58892; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR   InterPro; IPR002933; Peptidase_M20.
DR   InterPro; IPR011650; Peptidase_M20_dimer.
DR   Pfam; PF07687; M20_dimer; 1.
DR   Pfam; PF01546; Peptidase_M20; 1.
DR   SUPFAM; SSF55031; SSF55031; 1.
PE   3: Inferred from homology;
KW   Cobalt; Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..346
FT                   /note="Uncharacterized metallohydrolase MJ1497"
FT                   /id="PRO_0000185353"
FT   ACT_SITE        67
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        115
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         65
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         89
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         89
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         116
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         145
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         319
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   346 AA;  39800 MW;  97E0E7B0DE358CFA CRC64;
     MIIMDYLKIL EDLVKIRTDN RIGVKKAFKY LSNLFNNLGI KNTIIEGCFV AYKEKENFDL
     ILNSHIDTVK IQSNFKKDDN NFYGTGVIDA KGNVVLMIHA FLNSNNSLLV ISPDEETESN
     GIYNFCQYLR NKNKIQRGIK CIVGEPTDLN VCIGHKGRFE YIVESFGEAR HASSQGLNPI
     EILSRVILDL KNLPLEKIKV DKIYSSSITP TIIKGGIQSN IIPDYAYVLF DVRSVEKDII
     KKIDDFLSQK NYSKHIKSSL NPERHYANFY MLENKELINK LSKHFKISFF NATCEAYYFN
     KFLKADTIIY GVGKLELAHS KEEYLNLNDF DRGIKEVEKL AELMIE