ID   Y1498_MYCTU             Reviewed;         269 AA.
AC   P9WLW9; L0T9L2; P71779;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 2.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Uncharacterised methyltransferase Rv1498c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv1498c; ORFNames=MTCY277.20c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 8-15, AND SEQUENCE REVISION TO N-TERMINUS.
RC   STRAIN=H37Rv;
RX   PubMed=34915127; DOI=10.1016/j.ygeno.2021.12.001;
RA   Shi J., Meng S., Wan L., Zhang Z., Jiang S., Zhu H., Dai E., Chang L.,
RA   Gao H., Wan K., Zhang L., Zhao X., Liu H., Lyu Z., Zhang Y., Xu P.;
RT   "Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct
RT   annotated encoding genes.";
RL   Genomics 114:292-304(2021).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: The predicted start codon is CTG.
CC       {ECO:0000305|PubMed:34915127}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP44259.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
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DR   EMBL; AL123456; CCP44259.1; ALT_INIT; Genomic_DNA.
DR   PIR; E70712; E70712.
DR   RefSeq; NP_216014.1; NC_000962.3.
DR   AlphaFoldDB; P9WLW9; -.
DR   SMR; P9WLW9; -.
DR   STRING; 83332.Rv1498c; -.
DR   PaxDb; P9WLW9; -.
DR   DNASU; 886503; -.
DR   GeneID; 886503; -.
DR   KEGG; mtu:Rv1498c; -.
DR   TubercuList; Rv1498c; -.
DR   eggNOG; COG2226; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Methyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..269
FT                   /note="Uncharacterised methyltransferase Rv1498c"
FT                   /id="PRO_0000103860"
SQ   SEQUENCE   269 AA;  30021 MW;  D7B05B47CA4C487F CRC64;
     MRCIIKRLFQ NILTRSKRGS ADGGSAEALP PKSLRQFVGG AYKEVGAEFV GYLVDLCGLQ
     PDEAVLDVGC GSGRMALPLT GYLNSEGRYA GFDISQKAIA WCQEHITSAH PNFQFEVSDI
     YNSLYNPKGK YQSLDFRFPY PDASFDVVFL TSVFTHMFPP DVEHYLDEIS RVLKPGGRCL
     CTYFLLNDES LAHIAEGKSA HNFQHEGPGY RTIHKKRPEE AIGLPETFVR DVYGKFGLAV
     HEPLHYGSWS GREPRLSFQD IVIATKTAS