Y1507_DEIRA
ID Y1507_DEIRA Reviewed; 377 AA.
AC Q9RU85;
DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Putative zinc metalloprotease DR_1507;
DE EC=3.4.24.-;
GN OrderedLocusNames=DR_1507;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR EMBL; AE000513; AAF11073.1; -; Genomic_DNA.
DR PIR; E75388; E75388.
DR RefSeq; NP_295230.1; NC_001263.1.
DR RefSeq; WP_010888146.1; NZ_CP015081.1.
DR AlphaFoldDB; Q9RU85; -.
DR STRING; 243230.DR_1507; -.
DR EnsemblBacteria; AAF11073; AAF11073; DR_1507.
DR KEGG; dra:DR_1507; -.
DR PATRIC; fig|243230.17.peg.1710; -.
DR eggNOG; COG0750; Bacteria.
DR HOGENOM; CLU_025778_1_3_0; -.
DR InParanoid; Q9RU85; -.
DR OMA; QYMVGFG; -.
DR OrthoDB; 1395197at2; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR004387; Pept_M50_Zn.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR42837; PTHR42837; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS00142; ZINC_PROTEASE; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Metal-binding; Metalloprotease;
KW Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc.
FT CHAIN 1..377
FT /note="Putative zinc metalloprotease DR_1507"
FT /id="PRO_0000088440"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 109..198
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT ACT_SITE 31
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ SEQUENCE 377 AA; 40486 MW; 58553505806DC64C CRC64;
MNVLQGMAAA LTPLGLLWTA IIFGVSVFLH ELAHYGLARA QGVRVNSFSV GMGPVLFKKL
WRGTEWRVSL LPIGGYVEID GMAPVEDADG QWRLPTRGFA ALPAWGKIAV LLAGPLTNLL
LTLGLMTVSF TSQGIPALDR ARIESVETGS RAQALGLRAG DVITAIDGQD IPETRRVGGQ
EAAGYEGVRD ALAQAGRHTF TVERAEQGQP VQTRQVAFDW QPTVNGQRQL LGIRYGPDVR
QVGVGQAFVT SVDTTVRAVP QLVGAFTGLF KKFFTLDISQ DQNVSGPIGT AEVISRAAAL
SPWALVQVAT LLNLSLAFFN LIPIPGLDGG RILLVLVSAL RGRPLSFQQE QAINLGGFAF
VMLLTLFVVV RDVSRFF