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Y1507_DEIRA
ID   Y1507_DEIRA             Reviewed;         377 AA.
AC   Q9RU85;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Putative zinc metalloprotease DR_1507;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=DR_1507;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR   EMBL; AE000513; AAF11073.1; -; Genomic_DNA.
DR   PIR; E75388; E75388.
DR   RefSeq; NP_295230.1; NC_001263.1.
DR   RefSeq; WP_010888146.1; NZ_CP015081.1.
DR   AlphaFoldDB; Q9RU85; -.
DR   STRING; 243230.DR_1507; -.
DR   EnsemblBacteria; AAF11073; AAF11073; DR_1507.
DR   KEGG; dra:DR_1507; -.
DR   PATRIC; fig|243230.17.peg.1710; -.
DR   eggNOG; COG0750; Bacteria.
DR   HOGENOM; CLU_025778_1_3_0; -.
DR   InParanoid; Q9RU85; -.
DR   OMA; QYMVGFG; -.
DR   OrthoDB; 1395197at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837; PTHR42837; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Metal-binding; Metalloprotease;
KW   Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc.
FT   CHAIN           1..377
FT                   /note="Putative zinc metalloprotease DR_1507"
FT                   /id="PRO_0000088440"
FT   TRANSMEM        108..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          109..198
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   ACT_SITE        31
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         34
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   377 AA;  40486 MW;  58553505806DC64C CRC64;
     MNVLQGMAAA LTPLGLLWTA IIFGVSVFLH ELAHYGLARA QGVRVNSFSV GMGPVLFKKL
     WRGTEWRVSL LPIGGYVEID GMAPVEDADG QWRLPTRGFA ALPAWGKIAV LLAGPLTNLL
     LTLGLMTVSF TSQGIPALDR ARIESVETGS RAQALGLRAG DVITAIDGQD IPETRRVGGQ
     EAAGYEGVRD ALAQAGRHTF TVERAEQGQP VQTRQVAFDW QPTVNGQRQL LGIRYGPDVR
     QVGVGQAFVT SVDTTVRAVP QLVGAFTGLF KKFFTLDISQ DQNVSGPIGT AEVISRAAAL
     SPWALVQVAT LLNLSLAFFN LIPIPGLDGG RILLVLVSAL RGRPLSFQQE QAINLGGFAF
     VMLLTLFVVV RDVSRFF
 
 
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