ID   Y1510_DICDI             Reviewed;        1031 AA.
AC   Q54EH3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=GTPase-activating protein DDB_G0291510;
GN   ORFNames=DDB_G0291510;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
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DR   EMBL; AAFI02000177; EAL61739.1; -; Genomic_DNA.
DR   RefSeq; XP_635267.1; XM_630175.1.
DR   AlphaFoldDB; Q54EH3; -.
DR   SMR; Q54EH3; -.
DR   STRING; 44689.DDB0233060; -.
DR   PaxDb; Q54EH3; -.
DR   EnsemblProtists; EAL61739; EAL61739; DDB_G0291510.
DR   GeneID; 8628211; -.
DR   KEGG; ddi:DDB_G0291510; -.
DR   dictyBase; DDB_G0291510; -.
DR   eggNOG; KOG2063; Eukaryota.
DR   eggNOG; KOG3686; Eukaryota.
DR   HOGENOM; CLU_294309_0_0_1; -.
DR   InParanoid; Q54EH3; -.
DR   OMA; VENPEEC; -.
DR   Reactome; R-DDI-392517; Rap1 signalling.
DR   PRO; PR:Q54EH3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; -; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; SSF111347; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..1031
FT                   /note="GTPase-activating protein DDB_G0291510"
FT                   /id="PRO_0000368231"
FT   DOMAIN          186..404
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00165"
FT   DOMAIN          471..881
FT                   /note="CNH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00795"
FT   REGION          18..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          920..950
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1031 AA;  114371 MW;  70CE87E9EBE5B155 CRC64;
     MQTFSNINLV KPSRDWRVEK GDIDENNSGS INNRPLSPTL FSSNSSNNNN NNTTNNYIAV
     NGNLVLGVNG VGVGEQAQSL DIAVENPEEC ILWYYNYFLG KSHQNYLGTL DNGDVFGASI
     KKEEYAIEGE YSYKTIIWTL EGIERQWFQL KKHASTTPTD IIKKALPRLQ IKKIKEIDSP
     DLLKDFKDLE QTQTEINYKF GLLLARPNQS SEDDFYNNVE HSPKWTEFLN LLGDTVVLNS
     FKGYRGGLDV NNNTTGTHSL YTSLKGYEVM FHVSTMLPHS KADSQQIERK RHLGNDIVII
     IFYDCDPSDP IIPWDPSTVN SNFNHIFAVV RPADENNYHV EIVIKHGIAK FGPVLPTHSI
     FPKNSTFKEF LITKLVNAQR AALNSAPSFA TKLKRTFKDQ LESIYKKHSS SSSSLSFVPK
     RRSSSVSNIN KGRELKVKDP KYGSGFFKLL SKDSNKTQVF DTEILFSKSL NEKINCLDVV
     ESDENNSTLI VATEESIYLL KSNMITGEQL FQKIIVMKDV IRLTLVKPLK ILLVLTGKGL
     CFFEMDTIFQ QFNNLSTNST IPSSYAIPIP TTPTTSNNNG GSGFFSSNNL SNGHTSLRWS
     KSGIIAAGLI NNNNNSNSIN SINSNNNNNI NNSSINNNNG GNTNILAPSV FLSVNNNNNN
     SGNNIFNNNN NNNNNGGLNN SSENILTVIG EDSIKVKKIV GTKGCTVYGY TKGDNEGQEE
     DITLLYVGLK KTLLLYEWNK GEFVKSRELP LMDNIKTLCA IAPGMICVGI QKEFLLIDIF
     TQTIKELYKK SDSEPVKALS LDNEILLCFN NIGIFVDESG NKTRQFELKW GSTPSSLALV
     PSYVLGISGP LIEVRTLLNG NIIQSLPANI SLSNDDCNLD NHYHHHEIIN NCSAINIVNN
     QLSDNIENIN NLNINNNNGN NNYNNNGNNS NGGNNNNNNN NNNGCNNSLI NLDQETNNLM
     SENSNNGAEN VYSFSTFNDI AHVDNGNIYV ASSSKGLSCI LRIKQNIQLN VLPSPSSSPL
     KPSLLLPPSP L