ID   CAPSD_HCYV5             Reviewed;         219 AA.
AC   D4N3P3;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   12-AUG-2020, entry version 15.
DE   RecName: Full=Capsid protein;
GN   Name=Cap; ORFNames=ORF2;
OS   Human associated cyclovirus 1 (isolate Homo sapiens/Pakistan/PK5510/2007)
OS   (HuCyV-1) (Cyclovirus PK5510).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Cirlivirales; Circoviridae; Cyclovirus.
OX   NCBI_TaxID=742918;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20007276; DOI=10.1128/jvi.02109-09;
RA   Li L., Kapoor A., Slikas B., Bamidele O.S., Wang C., Shaukat S.,
RA   Masroor M.A., Wilson M.L., Ndjango J.B., Peeters M., Gross-Camp N.D.,
RA   Muller M.N., Hahn B.H., Wolfe N.D., Triki H., Bartkus J., Zaidi S.Z.,
RA   Delwart E.;
RT   "Multiple diverse circoviruses infect farm animals and are commonly found
RT   in human and chimpanzee feces.";
RL   J. Virol. 84:1674-1682(2010).
CC   -!- FUNCTION: Self-assembles to form the virion icosahedral capsid with a
CC       T=1 symmetry. This very small capsid (17-22 nm in diameter) allows the
CC       virus to be very stable in the environment and resistant to some
CC       disinfectants, including detergents. Essential for the initial
CC       attachment to heparan sulfate moieties and chondroitin sulfate B of the
CC       host cell surface proteoglycans. After attachment, the virus is
CC       endocytosed and traffics to the nucleus. The capsid protein binds and
CC       transports the viral genome and Rep across the nuclear envelope.
CC       {ECO:0000250|UniProtKB:Q9YUC8}.
CC   -!- SUBUNIT: Homomultimer. Assembles in the nucleus, presumably in an
CC       immature form, then migrates to the cytoplasm once assembled as mature
CC       virion. Interacts with Rep; this interaction relocates Rep into the
CC       nucleus. {ECO:0000250|UniProtKB:Q9YUC8}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:Q9YUC8}.
CC       Virion {ECO:0000250|UniProtKB:Q9YUC8}.
CC   -!- SIMILARITY: Belongs to the circoviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; GQ404847; ADD62458.1; -; Genomic_DNA.
DR   Proteomes; UP000146794; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Capsid protein; DNA-binding; Host nucleus; Host-virus interaction;
KW   Reference proteome; T=1 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Viral penetration into host nucleus; Virion; Virus endocytosis by host;
KW   Virus entry into host cell.
FT   CHAIN           1..219
FT                   /note="Capsid protein"
FT                   /id="PRO_0000445706"
FT   REGION          5..29
FT                   /note="Nuclear localization signals"
FT                   /evidence="ECO:0000250|UniProtKB:O56129"
SQ   SEQUENCE   219 AA;  25006 MW;  7873CD3E46B7F57E CRC64;
     MPFSRRRRVV RRRKPVRRLR RRRRRFFKRA GRGSFRVKLT RFVSITQDIS KTTQFSFEIT
     PSDFTEFATL ADAFEAVRFT RAKVTVLPQQ NVSNNSTSLI PAYCMFPWHK ELPTVATFNG
     FLSIDRAKCF RGTQVGIQHY VPSTLDSIQT KGAAGYEVQS VQTKYKPTIQ ISGGASTVVL
     YTGALGMQAL SDAPENAQAH YNIKIDMWCT FINQTSFNK