ID   Y152_HAEIN              Reviewed;         235 AA.
AC   P43954;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Putative 4'-phosphopantetheinyl transferase HI_0152;
DE            EC=2.7.8.-;
GN   OrderedLocusNames=HI_0152;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: May transfer the 4'-phosphopantetheine moiety from coenzyme A
CC       (CoA) to a serine residue of a carrier protein domain. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the P-Pant transferase superfamily.
CC       Gsp/Sfp/HetI/AcpT family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21831.1; -; Genomic_DNA.
DR   PIR; H64002; H64002.
DR   RefSeq; NP_438322.1; NC_000907.1.
DR   RefSeq; WP_005694435.1; NC_000907.1.
DR   AlphaFoldDB; P43954; -.
DR   SMR; P43954; -.
DR   STRING; 71421.HI_0152; -.
DR   DNASU; 951063; -.
DR   EnsemblBacteria; AAC21831; AAC21831; HI_0152.
DR   KEGG; hin:HI_0152; -.
DR   PATRIC; fig|71421.8.peg.155; -.
DR   eggNOG; COG2091; Bacteria.
DR   HOGENOM; CLU_102894_0_0_6; -.
DR   OMA; SWCLREA; -.
DR   BioCyc; HINF71421:G1GJ1-164-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IBA:GO_Central.
DR   Gene3D; 3.90.470.20; -; 1.
DR   InterPro; IPR008278; 4-PPantetheinyl_Trfase_dom.
DR   InterPro; IPR037143; 4-PPantetheinyl_Trfase_dom_sf.
DR   Pfam; PF01648; ACPS; 1.
DR   SUPFAM; SSF56214; SSF56214; 2.
PE   3: Inferred from homology;
KW   Magnesium; Metal-binding; Reference proteome; Transferase.
FT   CHAIN           1..235
FT                   /note="Putative 4'-phosphopantetheinyl transferase HI_0152"
FT                   /id="PRO_0000206085"
FT   BINDING         112
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         114
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         155
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   235 AA;  27808 MW;  CC9B6219BBA561DE CRC64;
     MTTYIAYGNI NQPFSLESLP DELIPENLYQ IETDSSRVFQ RHQCRRLAHL LLFQLLKIAG
     KSTALLSQIH RTESGRPYFL DERIDFNISH SGDWVAVILD IRNEEKSAVG IDIEFPKIRN
     FTALMEHIAP KEEIDWFHHQ QDSLNAFYRC WCLREAVLKS QGFGIVKLSN VRHFPEQQKI
     FSDYCPQGQL WFTDELPIYL AAFVNHQEKL PHFYEWNRES LQIKELEKYV LYEVN