ID   Y1533_MYCBO             Reviewed;         336 AA.
AC   P63578; A0A1R3XYX5; P71777; X2BI73;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable GTPase Mb1533;
DE            EC=3.6.-.-;
GN   OrderedLocusNames=BQ2027_MB1533;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Probable GTPase. May also bind and hydrolyze ATP. May
CC       function as chaperone (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=SIU00136.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000250|UniProtKB:P9WPZ1};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LT708304; SIU00136.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_855185.1; NC_002945.3.
DR   RefSeq; WP_003407596.1; NC_002945.4.
DR   AlphaFoldDB; P63578; -.
DR   SMR; P63578; -.
DR   EnsemblBacteria; SIU00136; SIU00136; BQ2027_MB1533.
DR   GeneID; 45425476; -.
DR   PATRIC; fig|233413.5.peg.1675; -.
DR   OMA; WMWERID; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR005129; GTPase_ArgK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23408; PTHR23408; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00750; lao; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; GTP-binding; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..336
FT                   /note="Probable GTPase Mb1533"
FT                   /id="PRO_0000157818"
FT   BINDING         67..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         209
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         245..247
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   336 AA;  36459 MW;  8B4AACF079CE66C7 CRC64;
     MAMMAASHDD DTVDGLATAV RGGDRAALPR AITLVESTRP DHREQAQQLL LRLLPDSGNA
     HRVGITGVPG VGKSTAIEAL GMHLIERGHR VAVLAVDPSS TRTGGSILGD KTRMARLAVH
     PNAYIRPSPT SGTLGGVTRA TRETVVLLEA AGFDVILIET VGVGQSEVAV ANMVDTFVLL
     TLARTGDQLQ GIKKGVLELA DIVVVNKADG EHHKEARLAA RELSAAIRLI YPREALWRPP
     VLTMSAVEGR GLAELWDTVE RHRQVLTGAG EFDARRRDQQ VDWTWQLVRD AVLDRVWSNP
     TVRKVRSELE RRVRAGELTP ALAAQQILEI ANLTDR