ID   Y1533_SACS2             Reviewed;         384 AA.
AC   Q97Y16;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Putative dioxygenase SSO1533;
DE            EC=1.13.-.-;
GN   OrderedLocusNames=SSO1533;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
CC       {ECO:0000305}.
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DR   EMBL; AE006641; AAK41755.1; -; Genomic_DNA.
DR   PIR; D90312; D90312.
DR   RefSeq; WP_010923457.1; NC_002754.1.
DR   AlphaFoldDB; Q97Y16; -.
DR   SMR; Q97Y16; -.
DR   STRING; 273057.SSO1533; -.
DR   PRIDE; Q97Y16; -.
DR   DNASU; 1454534; -.
DR   EnsemblBacteria; AAK41755; AAK41755; SSO1533.
DR   GeneID; 44130345; -.
DR   KEGG; sso:SSO1533; -.
DR   PATRIC; fig|273057.12.peg.1572; -.
DR   eggNOG; arCOG06976; Archaea.
DR   HOGENOM; CLU_053101_0_0_2; -.
DR   InParanoid; Q97Y16; -.
DR   OMA; PYNHSNI; -.
DR   PhylomeDB; Q97Y16; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IBA:GO_Central.
DR   GO; GO:0006570; P:tyrosine metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR11056; PTHR11056; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   3: Inferred from homology;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..384
FT                   /note="Putative dioxygenase SSO1533"
FT                   /id="PRO_0000220260"
FT   BINDING         296
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         302
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         332
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   384 AA;  44562 MW;  2656E16E1C36EE9F CRC64;
     MVFYHRQGEL PKKRHTVFMK DGKLMREEVF GLNGFNGRYS LLYHLNPPTR IMKLGEWKSN
     TIGEWKDAEY RHHKLSTSKL RKSSDVFLDR IALIFNDNLI ISFSKVDEGD TKLFYRNADF
     DEIYYVHSGE ILFKSVFGEI EVKEGDYLVI PRGTTYTLSF KKNAELFIIE GKQIEVPKDY
     RNEYGQLVEG SFYYNRDLKL PVLRTYDENG NYKLVIKTVN GFQLVELDTH PFDVVGWDGY
     LYPFALSVYD LEPITGKLHQ PPTAYTTFAA DDFVVCTFVP RLFDYHPQSV PISYYHNNID
     AEEIIFYSSG QFMSRRGINK GDITLHRGGH IHGPQPSAVE ASLNKRGTYN DEVAIMVETQ
     KRVKVSIYAK EIDDPTYPLS WYTS