ID   Y153_MYCTA              Reviewed;         310 AA.
AC   A5TYM1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MRA_0153;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MRA_0153;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000611; ABQ71871.1; -; Genomic_DNA.
DR   RefSeq; WP_003900814.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5TYM1; -.
DR   SMR; A5TYM1; -.
DR   STRING; 419947.MRA_0153; -.
DR   EnsemblBacteria; ABQ71871; ABQ71871; MRA_0153.
DR   GeneID; 45424112; -.
DR   KEGG; mra:MRA_0153; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; PMDITEL; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..310
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MRA_0153"
FT                   /id="PRO_0000361223"
FT   BINDING         132
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         161..162
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  34016 MW;  1B27617869F6059E CRC64;
     MRTHDDTWDI KTSVGATAVM VAAARAVETD RPDPLIRDPY ARLLVTNAGA GAIWEAMLDP
     TLVAKAAAID AETAAIVAYL RSYQAVRTNF FDTYFASAVA AGIRQVVILA SGLDSRAYRL
     DWPAGTIVYE IDQPKVLSYK STTLAENGVT PSAGRREVPA DLRQDWPAAL RDAGFDPTAR
     TAWLAEGLLM YLPAEAQDRL FTQVGAVSVA GSRIAAETAP VHGEERRAEM RARFKKVADV
     LGIEQTIDVQ ELVYHDQDRA SVADWLTDHG WRARSQRAPD EMRRVGRWVE GVPMADDPTA
     FAEFVTAERL