Y1542_HAEIN
ID Y1542_HAEIN Reviewed; 184 AA.
AC P45244;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Putative NAD(P)H nitroreductase HI_1542;
DE EC=1.-.-.-;
GN OrderedLocusNames=HI_1542;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC Note=Binds 1 FMN per subunit. {ECO:0000250};
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR EMBL; L42023; AAC23192.1; -; Genomic_DNA.
DR PIR; D64172; D64172.
DR RefSeq; NP_439691.1; NC_000907.1.
DR RefSeq; WP_005693567.1; NC_000907.1.
DR AlphaFoldDB; P45244; -.
DR SMR; P45244; -.
DR STRING; 71421.HI_1542; -.
DR DNASU; 950405; -.
DR EnsemblBacteria; AAC23192; AAC23192; HI_1542.
DR KEGG; hin:HI_1542; -.
DR PATRIC; fig|71421.8.peg.1613; -.
DR eggNOG; COG0778; Bacteria.
DR HOGENOM; CLU_070764_5_0_6; -.
DR OMA; IPEWEQV; -.
DR PhylomeDB; P45244; -.
DR BioCyc; HINF71421:G1GJ1-1562-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd02135; YdjA-like; 1.
DR Gene3D; 3.40.109.10; -; 1.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR InterPro; IPR026021; YdjA-like.
DR Pfam; PF00881; Nitroreductase; 1.
DR PIRSF; PIRSF000232; YdjA; 1.
DR SUPFAM; SSF55469; SSF55469; 1.
PE 3: Inferred from homology;
KW Flavoprotein; FMN; NAD; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..184
FT /note="Putative NAD(P)H nitroreductase HI_1542"
FT /id="PRO_0000169004"
FT BINDING 10..12
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 35
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000250"
FT BINDING 39
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000250"
FT BINDING 122..127
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255"
FT BINDING 132..134
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 184 AA; 20400 MW; F2EBDC99020C1025 CRC64;
MDALTLLTTR KSNKKLTAPA PNAEQLERIF EAAMRAPDHG KLHPYHFIVM ENESLNKLET
LLKAAVVEFD LGEEKLMKAE NLAHRAPMVI GVVAKIDPTI AKVPGWEQML SAGCATYGLQ
LAAQAQGFDN VWISGKWVNG TALREAFGCR EQDRVIALVM IGTGMEKAER ECRVIDTKDF
VTYL
