ID   Y1543_MYCTO             Reviewed;         341 AA.
AC   P9WGS0; L0T756; P66779; Q10783;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Uncharacterized oxidoreductase MT1595;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT1595;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK45861.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK45861.1; ALT_INIT; Genomic_DNA.
DR   PIR; D70761; D70761.
DR   RefSeq; WP_003407734.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGS0; -.
DR   SMR; P9WGS0; -.
DR   EnsemblBacteria; AAK45861; AAK45861; MT1595.
DR   GeneID; 45425526; -.
DR   KEGG; mtc:MT1595; -.
DR   PATRIC; fig|83331.31.peg.1716; -.
DR   HOGENOM; CLU_010194_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..341
FT                   /note="Uncharacterized oxidoreductase MT1595"
FT                   /id="PRO_0000428313"
FT   REGION          309..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        207
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         58..82
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         194
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   341 AA;  36821 MW;  D0650324DF22575F CRC64;
     MNLGDLTNFV EKPLAAVSNI VNTPNSAGRY RPFYLRNLLD AVQGRNLNDA VKGKVVLITG
     GSSGIGAAAA KKIAEAGGTV VLVARTLENL ENVANDIRAI RGNGGTAHVY PCDLSDMDAI
     AVMADQVLGD LGGVDILINN AGRSIRRSLE LSYDRIHDYQ RTMQLNYLGA VQLILKFIPG
     MRERHFGHIV NVSSVGVQTR APRFGAYIAS KAALDSLCDA LQAETVHDNV RFTTVHMALV
     RTPMISPTTI YDKFPTLTPD QAAGVITDAI VHRPRRASSP FGQFAAVADA VNPAVMDRVR
     NRAFNMFGDS SAAKGSESQT DTSELDKRSE TFVRATRGIH W