ID   Y1543_MYCTU             Reviewed;         341 AA.
AC   P9WGS1; L0T756; P66779; Q10783;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized oxidoreductase Rv1543;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv1543; ORFNames=MTCY48.22c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP44307.1; -; Genomic_DNA.
DR   PIR; D70761; D70761.
DR   RefSeq; NP_216059.1; NC_000962.3.
DR   RefSeq; WP_003407734.1; NZ_NVQJ01000004.1.
DR   AlphaFoldDB; P9WGS1; -.
DR   SMR; P9WGS1; -.
DR   STRING; 83332.Rv1543; -.
DR   PaxDb; P9WGS1; -.
DR   DNASU; 886400; -.
DR   GeneID; 45425526; -.
DR   GeneID; 886400; -.
DR   KEGG; mtu:Rv1543; -.
DR   TubercuList; Rv1543; -.
DR   eggNOG; COG1028; Bacteria.
DR   OMA; QATRGIH; -.
DR   PhylomeDB; P9WGS1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..341
FT                   /note="Uncharacterized oxidoreductase Rv1543"
FT                   /id="PRO_0000054856"
FT   REGION          309..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        207
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         58..82
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         194
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   341 AA;  36821 MW;  D0650324DF22575F CRC64;
     MNLGDLTNFV EKPLAAVSNI VNTPNSAGRY RPFYLRNLLD AVQGRNLNDA VKGKVVLITG
     GSSGIGAAAA KKIAEAGGTV VLVARTLENL ENVANDIRAI RGNGGTAHVY PCDLSDMDAI
     AVMADQVLGD LGGVDILINN AGRSIRRSLE LSYDRIHDYQ RTMQLNYLGA VQLILKFIPG
     MRERHFGHIV NVSSVGVQTR APRFGAYIAS KAALDSLCDA LQAETVHDNV RFTTVHMALV
     RTPMISPTTI YDKFPTLTPD QAAGVITDAI VHRPRRASSP FGQFAAVADA VNPAVMDRVR
     NRAFNMFGDS SAAKGSESQT DTSELDKRSE TFVRATRGIH W