ID   Y1546_AQUAE             Reviewed;         322 AA.
AC   O67500;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Uncharacterized phosphosugar isomerase aq_1546;
GN   OrderedLocusNames=aq_1546;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- SIMILARITY: Belongs to the SIS family. GutQ/KpsF subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000657; AAC07460.1; -; Genomic_DNA.
DR   PIR; B70434; B70434.
DR   RefSeq; NP_214065.1; NC_000918.1.
DR   RefSeq; WP_010881003.1; NC_000918.1.
DR   AlphaFoldDB; O67500; -.
DR   SMR; O67500; -.
DR   STRING; 224324.aq_1546; -.
DR   EnsemblBacteria; AAC07460; AAC07460; aq_1546.
DR   KEGG; aae:aq_1546; -.
DR   PATRIC; fig|224324.8.peg.1199; -.
DR   eggNOG; COG0517; Bacteria.
DR   eggNOG; COG0794; Bacteria.
DR   HOGENOM; CLU_040681_13_1_0; -.
DR   InParanoid; O67500; -.
DR   OMA; LMACLMR; -.
DR   OrthoDB; 571638at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd05014; SIS_Kpsf; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR004800; KdsD/KpsF-type.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR035474; SIS_Kpsf.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01380; SIS; 1.
DR   PIRSF; PIRSF004692; KdsD_KpsF; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   TIGRFAMs; TIGR00393; kpsF; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51464; SIS; 1.
PE   3: Inferred from homology;
KW   CBS domain; Isomerase; Reference proteome; Repeat.
FT   CHAIN           1..322
FT                   /note="Uncharacterized phosphosugar isomerase aq_1546"
FT                   /id="PRO_0000136583"
FT   DOMAIN          35..178
FT                   /note="SIS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT   DOMAIN          203..261
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          270..322
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   322 AA;  35115 MW;  74BE86D9B8FB2A69 CRC64;
     MEEKDLLEFA REVIREEIKG LERLLSSLDE NFSKAVEILR NCEGKVILTG IGKSGHIARK
     ISSTLSSTGT PSVFLHPAEA LHGDMGLLDS KDALIAISNS GESTEVLYVL QYAKALNIPV
     IGITGNEKSS LAKYSDVVLK IPVDREACPF NLAPTVSSTV TLALGDAIAM TLMKLKGFSQ
     EDFAKRHPAG ALGRKLRLVK DLYHTGEEVP IVKEDTSMKE AIIEMTAKGF GATAVVNEEG
     KLVGIITDGD LRRFVNRGGS FENTRAKDVM TKNPKTIKPD ELALKALRKM EDHNITVLIV
     VNEENEPIGI LHMHDILKAE LS