ID   Y1546_METJA             Reviewed;         345 AA.
AC   Q58941;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 3.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=UPF0219 protein MJ1546 {ECO:0000255|HAMAP-Rule:MF_01409};
GN   OrderedLocusNames=MJ1546;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. UPF0219 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01409}.
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DR   EMBL; L77117; AAB99564.1; -; Genomic_DNA.
DR   PIR; A64493; A64493.
DR   RefSeq; WP_010871070.1; NC_000909.1.
DR   AlphaFoldDB; Q58941; -.
DR   SMR; Q58941; -.
DR   STRING; 243232.MJ_1546; -.
DR   EnsemblBacteria; AAB99564; AAB99564; MJ_1546.
DR   GeneID; 1452454; -.
DR   KEGG; mja:MJ_1546; -.
DR   eggNOG; arCOG01767; Archaea.
DR   HOGENOM; CLU_039592_7_0_2; -.
DR   InParanoid; Q58941; -.
DR   OMA; YAKHKGK; -.
DR   OrthoDB; 12601at2157; -.
DR   PhylomeDB; Q58941; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IBA:GO_Central.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IBA:GO_Central.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 1.
DR   HAMAP; MF_01409; UPF0219; 1.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004656; FabH-rel.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR00748; HMG_CoA_syn_Arc; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..345
FT                   /note="UPF0219 protein MJ1546"
FT                   /id="PRO_0000057614"
SQ   SEQUENCE   345 AA;  37549 MW;  8FDA1A9379064F0C CRC64;
     MAGIVGYGAY IPKYRIKVEE IARVWNKDPE SIKKGLLVYE KAVPSLDEDT ATIAVEAARN
     ALKRAEIDPK DIGAVYVGSE SHPYAVKPTA TIVAEAIDAT PDLTAADLEF ACKAGTAGIQ
     MCMGLVESGL IKYGLAIGAD TAQGAPGDAL EYTAAAGGAA YIIGKSNVIA EFNGTYSYTT
     DTPDFWRREG KPYPRHGGRF TGEPAYFRHV INAAKGLMEK MGTKPEDYDY CVFHQPNGKF
     YIRVAKILGF KEEQYKIGLL TPYIGNTYSG AVPLGLSNVL DNCEGGERIL AVSYGSGAGS
     DAFDITVTDR INKVKDKAPK TAYYLERKEY IDYAIYAKFR KKIKM