ID   Y1546_STRP1             Reviewed;         142 AA.
AC   P0C0H5; P16963; Q48XN3;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Uncharacterized acetyltransferase SPy_1546/M5005_Spy1274;
DE            EC=2.3.1.-;
GN   OrderedLocusNames=SPy_1546, M5005_Spy1274;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. {ECO:0000305}.
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DR   EMBL; AE004092; AAK34338.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51892.1; -; Genomic_DNA.
DR   RefSeq; NP_269617.1; NC_002737.2.
DR   AlphaFoldDB; P0C0H5; -.
DR   SMR; P0C0H5; -.
DR   STRING; 1314.HKU360_01315; -.
DR   PaxDb; P0C0H5; -.
DR   EnsemblBacteria; AAK34338; AAK34338; SPy_1546.
DR   KEGG; spy:SPy_1546; -.
DR   KEGG; spz:M5005_Spy1274; -.
DR   PATRIC; fig|160490.10.peg.1351; -.
DR   HOGENOM; CLU_056607_9_0_9; -.
DR   OMA; ENLGYQS; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0004343; F:glucosamine 6-phosphate N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR039143; GNPNAT1.
DR   PANTHER; PTHR13355; PTHR13355; 1.
DR   Pfam; PF13673; Acetyltransf_10; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..142
FT                   /note="Uncharacterized acetyltransferase
FT                   SPy_1546/M5005_Spy1274"
FT                   /id="PRO_0000205420"
FT   DOMAIN          1..120
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   142 AA;  16020 MW;  B5709D6FC19E0ECA CRC64;
     MADKFDANDE TRTVYAVVYD NDQPVSTGQF LAETKIEARL TRIVTLADYC GCGYGAKVTE
     ALETYTRREG FYQLTIHSEL TAQTFYENLG YQSYGPKCLE DGEYCQSLAK TILKWEKNMD
     IAMLIAIVGG LLGCYLYLTK NN