ID   CAPSD_HV19S             Reviewed;         772 AA.
AC   O57043;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Major capsid protein;
DE   AltName: Full=Major coat protein;
OS   Helminthosporium victoriae virus-190S (Hv190SV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Chrymotiviricetes;
OC   Ghabrivirales; Totiviridae; Victorivirus.
OX   NCBI_TaxID=45237;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8901618; DOI=10.1073/pnas.93.22.12541;
RA   Huang S., Ghabrial S.A.;
RT   "Organization and expression of the double-stranded RNA genome of
RT   Helminthosporium victoriae 190S virus, a totivirus infecting a plant
RT   pathogenic filamentous fungus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:12541-12546(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Ghbarial S.A., Nibert M., Xu L.L., Talkington M.W.T.;
RT   "Victorivirus: a new genus in the family Totiviridae.";
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Capsid protein self-assembles to form an icosahedral capsid
CC       with a T=2 symmetry, 40 nm in diameter, and consisting of 60 capsid
CC       proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA
CC       and the polymerase and remains intact following cell entry to protect
CC       the dsRNA from degradation and to prevent unfavorable antiviral
CC       responses in the host cell during all the replication cycle of the
CC       virus. Nascent transcripts are transcribed within the structural
CC       confines of the virion and are extruded into the cytoplasm (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Binds and removes 5' cap structures from cellular mRNA.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the totivirus major capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; U41345; AAB94790.2; -; Genomic_RNA.
DR   RefSeq; NP_619669.2; NC_003607.2.
DR   SMR; O57043; -.
DR   GeneID; 940191; -.
DR   KEGG; vg:940191; -.
DR   Proteomes; UP000000352; Genome.
DR   GO; GO:0039616; C:T=2 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   InterPro; IPR008871; Totivirus_coat.
DR   Pfam; PF05518; Totivirus_coat; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Reference proteome; T=2 icosahedral capsid protein; Virion.
FT   CHAIN           1..772
FT                   /note="Major capsid protein"
FT                   /id="PRO_0000404514"
FT   REGION          593..772
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..747
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   772 AA;  81360 MW;  DBFD66D7BD7915E5 CRC64;
     MSHTTITNFL AGVIARPQGG NITSDETFRR YRTIVRTSAT IGGNEDSRTT SIFHEIGRAV
     NTKGKALAVA GMEAPLVEAS YPTNAVLVED FIGLAKKYTN FSATFEYSSL AGVVERLARG
     LAACSVFEDV TSTDLRGNNP LAVHALATYD GPVNSLTSAV FIPRLVNNAL TGDVFAVLCN
     CVAGEGGTVV TDTIELDANT RQPIVPEVGP LGVPGAIVDA LRLLGSNMIA SDQGPLFALA
     LTRGIHRVLS VVGHTDEGGI VRDLLRCGGF GLPFGGIHYG LEEYSGLPAL QFNSAAATAA
     YVDGIALVTA AVVAHADPGE RYNGEWFPTF FDGTTHADTM RRSGDSTEGT AAMADRNRAQ
     LLARQQLFWR PYITALGACF STAGDISVAE RFQCAASHSL GADPRHLRLP SVAPYFWIEP
     TGLIPHDFLG SVAEEEGFAS YCWRDTTRTR PAWDSIVLSG ARDTTFSAYH IRMKGARTAW
     FLAHWLGHPE NGLGATRVRQ LDPNAVLHPG PCEGNEQVRD RVEADLPLTD YLWRRGQSPF
     PAAGELLNLT SEWGILFRHV TFTDDGDLNP EHLPAAHEMA DTTVTMTVGR PIGIAPGRSN
     AGDNQARRAR TRASVELSAA SRRARVFGRP DVGEMPTLTS APAPIPASPA YDGNRGGEAG
     GVTGRGNNRS AAPGHASWSE RQADGVPVNV TPHHNALRAP PFPRQQGALG GGGNVPLPPA
     PGAAPPPPPG PPNGPPAGPP PSDDGSSNPA APVPTAIHAP PAAAQADRAE GQ