ID   Y1563_METJA             Reviewed;         152 AA.
AC   Q58958;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Putative HTH-type transcriptional regulator MJ1563;
DE   AltName: Full=DNA-binding protein MJ1563;
GN   OrderedLocusNames=MJ1563;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RX   PubMed=12471609; DOI=10.1002/prot.10272;
RA   Ray S.S., Bonanno J.B., Chen H., de Lencastre H., Wu S., Tomasz A.,
RA   Burley S.K.;
RT   "X-ray structure of an M.jannaschii DNA-binding protein: implications for
RT   antibiotic resistance in S. aureus.";
RL   Proteins 50:170-173(2003).
CC   -!- SIMILARITY: Belongs to the GbsR family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99584.1; -; Genomic_DNA.
DR   PIR; B64495; B64495.
DR   PDB; 1KU9; X-ray; 2.80 A; A/B=1-152.
DR   PDBsum; 1KU9; -.
DR   AlphaFoldDB; Q58958; -.
DR   SMR; Q58958; -.
DR   STRING; 243232.MJ_1563; -.
DR   EnsemblBacteria; AAB99584; AAB99584; MJ_1563.
DR   KEGG; mja:MJ_1563; -.
DR   eggNOG; arCOG02795; Archaea.
DR   HOGENOM; CLU_107445_0_0_2; -.
DR   InParanoid; Q58958; -.
DR   OMA; KVWIKGE; -.
DR   PhylomeDB; Q58958; -.
DR   EvolutionaryTrace; Q58958; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR026282; MJ1563.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PIRSF; PIRSF006707; MJ1563; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..152
FT                   /note="Putative HTH-type transcriptional regulator MJ1563"
FT                   /id="PRO_0000160637"
FT   DOMAIN          7..106
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        44..68
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   HELIX           3..21
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   HELIX           26..37
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   HELIX           44..51
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   HELIX           55..67
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   STRAND          70..74
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   STRAND          83..86
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   HELIX           89..117
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   HELIX           123..133
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   HELIX           135..145
FT                   /evidence="ECO:0007829|PDB:1KU9"
FT   HELIX           146..149
FT                   /evidence="ECO:0007829|PDB:1KU9"
SQ   SEQUENCE   152 AA;  17609 MW;  ABD121B907F4271A CRC64;
     MIIMEEAKKL IIELFSELAK IHGLNKSVGA VYAILYLSDK PLTISDIMEE LKISKGNVSM
     SLKKLEELGF VRKVWIKGER KNYYEAVDGF SSIKDIAKRK HDLIAKTYED LKKLEEKCNE
     EEKEFIKQKI KGIERMKKIS EKILEALNDL DN