ID   CAPSD_LRVLG             Reviewed;         741 AA.
AC   Q02358;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 45.
DE   RecName: Full=Major capsid protein;
DE   AltName: Full=Major coat protein;
GN   Name=ORF2;
OS   Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Chrymotiviricetes;
OC   Ghabrivirales; Totiviridae; Leishmaniavirus.
OX   NCBI_TaxID=58103;
OH   NCBI_TaxID=5664; Leishmania major.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1382295; DOI=10.1073/pnas.89.18.8596;
RA   Stuart K.D., Weeks R., Guilbride L., Myler P.J.;
RT   "Molecular organization of Leishmania RNA virus 1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:8596-8600(1992).
CC   -!- FUNCTION: Capsid protein self-assembles to form an icosahedral capsid
CC       with a T=2 symmetry, 35 nm in diameter, and consisting of 60 capsid
CC       proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA
CC       and the polymerase and remains intact following cell entry to protect
CC       the dsRNA from degradation and to prevent unfavorable antiviral
CC       responses in the host cell during all the replication cycle of the
CC       virus. Nascent transcripts are transcribed within the structural
CC       confines of the virion and are extruded into the cytoplasm (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Binds and removes 5' cap structures from cellular mRNA.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the totivirus major capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; M92355; AAB50023.1; -; Genomic_RNA.
DR   PIR; B46171; B46171.
DR   RefSeq; NP_041190.1; NC_002063.1.
DR   SMR; Q02358; -.
DR   GeneID; 1446404; -.
DR   KEGG; vg:1446404; -.
DR   Proteomes; UP000006721; Genome.
DR   GO; GO:0039616; C:T=2 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   InterPro; IPR008871; Totivirus_coat.
DR   Pfam; PF05518; Totivirus_coat; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Reference proteome; T=2 icosahedral capsid protein; Virion.
FT   CHAIN           1..741
FT                   /note="Major capsid protein"
FT                   /id="PRO_0000404515"
FT   REGION          716..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   741 AA;  81749 MW;  894BAE24F0189F2E CRC64;
     MSDTPNSDKV ACGRKPMFCE IIKLANRKRL ILDTTGERVY DARINYCSTA DATVQADCHI
     YWRLKLRRTD AVFEEYTGQG YALDTASYPQ QYADIIRGYY SKHVSSALAA NTQHFVNVLA
     MLRHAGACIA HYCMTGKIDF DILSKKKHKN KEVVTLSSAD SLSFLPHSAL YLPSALRASD
     PEIFNVLYLL GCACDASIAM DNIANTSGAA KYAMPHYNPL QLSHALHVTI FYMLGLMDSC
     GYGEDAVLAL TAGLHSVTTV IAHSDEGAIT RDALRELSYT QPYGTMPVPI AGYFQHINVL
     FTTQPAWDQF AGIWDYVILA TAALVHLSDP GMTVNDVTYP TTLTTKVASV DGRNSDIAAQ
     MMHSATRFCD IYIENLCLFW GVVANPDGNA SQALLHAFNV VACGTEPNRH LEMNVMAPWY
     WVESSALFSD YSQFRSPISS AGYGPQSIYG ARLVLAATNS LEFTGEAGDY SAYRFEWTTM
     RHNPLFNILN KRVGDGLANV DFRLRPFNEW LLEGQPSRRS CDAVGHGTPT ATCNHKTPNR
     NTVDEFIWGS TSCDLFHPAE LTSYTAVCVR FRNYLSEADG DVRVLNTPTR EVIEGNVVTR
     CDGIRCLDSN KRIQHVPEVA RRYCMMARYL QARTFGALTI GDDIIRGFDK VDKVVKMHKS
     NNRLGQMPLI DVTGLCQPMI ETSTARASMT TRIDPNRLAA ATARIELPLA PRCTSSLIPS
     SDAVPEPEPH VGEPGNGSGC A