ID   CAPSD_MASV1             Reviewed;         775 AA.
AC   Q80KJ6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   02-JUN-2021, entry version 49.
DE   RecName: Full=Capsid polyprotein VP90;
GN   ORFNames=ORF2;
OS   Mink astrovirus 1 (MAstV-1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC   Stellavirales; Astroviridae; Mamastrovirus.
OX   NCBI_TaxID=1239574;
OH   NCBI_TaxID=452646; Neovison vison (American mink) (Mustela vison).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=14573813; DOI=10.1099/vir.0.19267-0;
RA   Mittelholzer C., Hedlund K.O., Englund L., Dietz H.H., Svensson L.;
RT   "Molecular characterization of a novel astrovirus associated with disease
RT   in mink.";
RL   J. Gen. Virol. 84:3087-3094(2003).
CC   -!- FUNCTION: The capsid polyprotein VP90 self-assembles and undergoes a
CC       proteolytic cleavage by host caspases to yield the VP70 virions. This
CC       immature virion is composed of 180 VP70 subunits with 90 dimeric spikes
CC       and displays a T=3 icosahedral symmetry. The mature virion is obtained
CC       by further cleavages resulting in three structural proteins VP25, VP27
CC       and VP34. This forms contains only 30 spikes located on the icosahedral
CC       2-fold axes. Plays a role in the attachment to target host cell. This
CC       attachment induces virion internalization through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- PTM: Specific enzymatic cleavages in vivo yield mature protein(s). VP90
CC       undergoes a cascade of proteolytic cleavages presumably mediated by
CC       host caspases and extracellular proteases (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the astroviridae capsid polyprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AY179509; AAO32083.1; -; Genomic_RNA.
DR   RefSeq; NP_795336.1; NC_004579.1.
DR   SMR; Q80KJ6; -.
DR   PRIDE; Q80KJ6; -.
DR   GeneID; 1482921; -.
DR   KEGG; vg:1482921; -.
DR   Proteomes; UP000007773; Genome.
DR   GO; GO:0039617; C:T=3 icosahedral viral capsid; ISS:UniProtKB.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; ISS:UniProtKB.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR004337; Capsid_astroviral.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF03115; Astro_capsid_N; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   T=3 icosahedral capsid protein; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..775
FT                   /note="Capsid polyprotein VP90"
FT                   /id="PRO_0000320239"
FT   REGION          25..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          707..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..54
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..727
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   775 AA;  84161 MW;  D8A0752997BB03DD CRC64;
     MASANQAAKA EAKKVIEKVA KEVIKETKNS AQRNQGPGKR WNSKKGRHMP KNNNNKGMKR
     TVDNEVKQKL KKEGLEGPRS RFSVRVSATI GKIGPNKEQG PELQIATFLH PSLMKEPNDG
     TNFGPLQAAA AQWGLWRLSS LEVKCTPLVG SSAVTGSIYR MSLNLTQSPG NASWGGLGAR
     KHKDIPAGKS VSWKLQRGDL AGPRQTWWMT DTNEEGGQSC GPMLEIHGLG KTSSTYQSQD
     WTGDLFIVEV LGRWEFTNYN AKPALGTLDR KSEDYASDAT GPGIMVGDDG VMKMTLPTAS
     SLARFMSDAS ERSPVNEGSV GETIWHIVDE GAGLASSVAP TPFSWLIKGA WWFVKKLAGR
     SGANADEQYV VYASLADAQN NKPVMANRFD HTKKATTLTV TQVNSPNTGP GVTQAAYHTE
     NPFPLVPATQ PPPPRSIVVV NATARPFGYV KYNTGDSNVK SHGKFDGTQY HFTLKRGSTV
     SYASAAYILT DVSMLTYEGN RVTGCYDPGW MEPTGITVHY RNESSAFGRV LAYEIDQWGS
     TSDNHFTIGV WLVQTIKDLP AHDTTVWPYI PLPYVSAGNC TAPPVQVALD KACVPYLTKV
     GVTSHQQCTV RQPQVRSGTF MLVYSIGTNT PATTAGFTTG QPLGEATNAS ALPEGKISTS
     GFWERALSAV APYQDFISVK FTLPQGPHAD PRVDALLDLI QQRFNLKPVD ASESEDEDED
     SPSGSEEEPC GEEPTPPQPT PRLKLAKEMM YEALRDSDWT HVDAEALLAA ISSKN