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Y1570_ARATH
ID   Y1570_ARATH             Reviewed;         852 AA.
AC   C0LGD6; Q9SYL1;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g05700;
DE            EC=2.7.11.1;
DE   Flags: Precursor;
GN   OrderedLocusNames=At1g05700; ORFNames=F3F20.15;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA   Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT   "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT   like protein kinase genes in Arabidopsis thaliana.";
RL   BMC Genomics 11:19-19(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- INTERACTION:
CC       C0LGD6; Q9LZV7: PXC2; NbExp=2; IntAct=EBI-16963709, EBI-1238200;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD30620.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC007153; AAD30620.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE27878.1; -; Genomic_DNA.
DR   EMBL; FJ708625; ACN59221.1; -; mRNA.
DR   PIR; C86191; C86191.
DR   RefSeq; NP_172061.2; NM_100450.3.
DR   AlphaFoldDB; C0LGD6; -.
DR   SMR; C0LGD6; -.
DR   BioGRID; 22319; 24.
DR   IntAct; C0LGD6; 25.
DR   STRING; 3702.AT1G05700.1; -.
DR   iPTMnet; C0LGD6; -.
DR   PaxDb; C0LGD6; -.
DR   PRIDE; C0LGD6; -.
DR   ProteomicsDB; 243032; -.
DR   EnsemblPlants; AT1G05700.1; AT1G05700.1; AT1G05700.
DR   GeneID; 837077; -.
DR   Gramene; AT1G05700.1; AT1G05700.1; AT1G05700.
DR   KEGG; ath:AT1G05700; -.
DR   Araport; AT1G05700; -.
DR   TAIR; locus:2031923; AT1G05700.
DR   eggNOG; ENOG502QQCZ; Eukaryota.
DR   HOGENOM; CLU_000288_41_1_1; -.
DR   InParanoid; C0LGD6; -.
DR   OMA; APRICFR; -.
DR   PhylomeDB; C0LGD6; -.
DR   PRO; PR:C0LGD6; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; C0LGD6; baseline and differential.
DR   Genevisible; C0LGD6; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR024788; Malectin-like_Carb-bd_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF12819; Malectin_like; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Glycoprotein; Kinase; Leucine-rich repeat; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..852
FT                   /note="Probable LRR receptor-like serine/threonine-protein
FT                   kinase At1g05700"
FT                   /id="PRO_0000387537"
FT   TOPO_DOM        26..510
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        511..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        532..852
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          410..432
FT                   /note="LRR 1"
FT   REPEAT          434..457
FT                   /note="LRR 2"
FT   REPEAT          458..479
FT                   /note="LRR 3"
FT   DOMAIN          570..843
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        693
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         576..584
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         597
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   MOD_RES         561
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O48814"
FT   MOD_RES         642
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:O48814"
FT   MOD_RES         697
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O48814"
FT   MOD_RES         727
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O48814"
FT   MOD_RES         728
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O48814"
FT   MOD_RES         733
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O48814"
FT   CARBOHYD        138
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        182
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        240
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        293
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        400
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        415
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        431
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        466
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   852 AA;  94981 MW;  A06D230DFE0A2FC1 CRC64;
     MEEFRFLYLI YSAAFALCLV VSVLAQDQSG FISIDCGIPS GSSYKDDTTG INYVSDSSFV
     ETGVSKSIPF TAQRQLQNLR SFPEGSRNCY TLIPIQGKGK KYLIRASFMY GNYDGENGSP
     EFDLFLGGNI WDTVLLSNGS SIVSKEVVYL SQSENIFVCL GNKGKGTPFI STLELRFLGN
     DNTTYDSPNG ALFFSRRWDL RSLMGSPVRY DDDVYDRIWI PRNFGYCREI NTSLPVTSDN
     NSYSLSSLVM STAMTPINTT RPITMTLENS DPNVRYFVYM HFAEVEDLSL KPNQTREFDI
     SINGVTVAAG FSPKYLQTNT FFLNPESQSK IAFSLVRTPK STLPPIVNAL EIYVANSFSQ
     SLTNQEDGDA VTSLKTSYKV KKNWHGDPCL PNDYIWEGLN CSYDSLTPPR ITSLNLSSSG
     LTGHISSSFS NLTMIQELDL SNNGLTGDIP EFLSKLKFLR VLNLENNTLT GSVPSELLER
     SNTGSFSLRL GENPGLCTEI SCRKSNSKKL VIPLVASFAA LFILLLLSGV FWRIRNRRNK
     SVNSAPQTSP MAKSENKLLF TFADVIKMTN NFGQVLGKGG FGTVYHGFYD NLQVAVKLLS
     ETSAQGFKEF RSEVEVLVRV HHVNLTALIG YFHEGDQMGL IYEFMANGNM ADHLAGKYQH
     TLSWRQRLQI ALDAAQGLEY LHCGCKPPIV HRDVKTSNIL LNEKNRAKLA DFGLSRSFHT
     ESRSHVSTLV AGTPGYLDPL CFETNGLNEK SDIYSFGVVL LEMITGKTVI KESQTKRVHV
     SDWVISILRS TNDVNNVIDS KMAKDFDVNS VWKVVELALS SVSQNVSDRP NMPHIVRGLN
     ECLQREESNK NY
 
 
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