ID   Y1570_MYCBO             Reviewed;         341 AA.
AC   P66780; A0A1R3Y0S6; Q10783; X2BIH0;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Uncharacterized oxidoreductase Mb1570;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=BQ2027_MB1570;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00173.1; -; Genomic_DNA.
DR   RefSeq; NP_855222.1; NC_002945.3.
DR   RefSeq; WP_003407734.1; NC_002945.4.
DR   AlphaFoldDB; P66780; -.
DR   SMR; P66780; -.
DR   EnsemblBacteria; SIU00173; SIU00173; BQ2027_MB1570.
DR   GeneID; 45425526; -.
DR   PATRIC; fig|233413.5.peg.1716; -.
DR   OMA; QATRGIH; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..341
FT                   /note="Uncharacterized oxidoreductase Mb1570"
FT                   /id="PRO_0000054857"
FT   REGION          309..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        207
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         58..82
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         194
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   341 AA;  36821 MW;  D0650324DF22575F CRC64;
     MNLGDLTNFV EKPLAAVSNI VNTPNSAGRY RPFYLRNLLD AVQGRNLNDA VKGKVVLITG
     GSSGIGAAAA KKIAEAGGTV VLVARTLENL ENVANDIRAI RGNGGTAHVY PCDLSDMDAI
     AVMADQVLGD LGGVDILINN AGRSIRRSLE LSYDRIHDYQ RTMQLNYLGA VQLILKFIPG
     MRERHFGHIV NVSSVGVQTR APRFGAYIAS KAALDSLCDA LQAETVHDNV RFTTVHMALV
     RTPMISPTTI YDKFPTLTPD QAAGVITDAI VHRPRRASSP FGQFAAVADA VNPAVMDRVR
     NRAFNMFGDS SAAKGSESQT DTSELDKRSE TFVRATRGIH W