Y1572_HAEIN
ID Y1572_HAEIN Reviewed; 366 AA.
AC P46495;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Putative integrase/recombinase HI_1572;
GN OrderedLocusNames=HI_1572;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=L42023; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; L42023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P46495; -.
DR SMR; P46495; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; -; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; SSF56349; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration; DNA recombination; DNA-binding; Reference proteome;
KW Viral genome integration; Virus entry into host cell.
FT CHAIN 1..366
FT /note="Putative integrase/recombinase HI_1572"
FT /id="PRO_0000197538"
FT DOMAIN 54..133
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT DOMAIN 168..331
FT /note="Tyr recombinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 308
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 318
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ SEQUENCE 366 AA; 42415 MW; 3A6D5ED685116590 CRC64;
MATIIKNGKR WHAQVRKFGV SKSAIFLTQA DAKKWAEMLE KQLESGKYNE IPDITLDELI
DKYLKEVTVT KRGKREERIR LLRLSRTPLA AISLQEIGKA HFREWRNQRL KEVSPTTVLR
ERSSLSALMA KTIEWDFITE NPLKYLEKPK APAPRTRRYN EHEIERLIFV SGYDVEHIEP
PKTLQNCTGA AFLFAIETAM RAGEIASLTW NNINFEKRTT FLPITKNGHS RTVPLSVKAI
EILQHLTSVK TESDPRVFQM EARQLDHNFR KLKKMEGLEN ANLHFHDTRR ERLAEKVDVM
VLAKISGHRD LSILQNTYYA PDMAEGYKTK AGYDLTPTKG LSQRNFFFFN ENFIVFTTNP
PIVIKL
