CAPSD_MSVN
ID CAPSD_MSVN Reviewed; 244 AA.
AC P06448;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 23-FEB-2022, entry version 88.
DE RecName: Full=Capsid protein;
DE AltName: Full=Coat protein;
DE Short=CP;
GN ORFNames=V1;
OS Maize streak virus genotype A (isolate Nigeria) (MSV).
OC Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC Geplafuvirales; Geminiviridae; Mastrevirus.
OX NCBI_TaxID=10823;
OH NCBI_TaxID=4498; Avena sativa (Oat).
OH NCBI_TaxID=217170; Axonopus compressus.
OH NCBI_TaxID=240436; Brachiaria deflexa.
OH NCBI_TaxID=4543; Cenchrus americanus (Pearl millet) (Pennisetum glaucum).
OH NCBI_TaxID=281129; Cenchrus polystachios.
OH NCBI_TaxID=4505; Coix lacryma-jobi (Job's tears).
OH NCBI_TaxID=270102; Dactyloctenium aegyptium.
OH NCBI_TaxID=66017; Digitaria.
OH NCBI_TaxID=90396; Echinochloa colona.
OH NCBI_TaxID=4511; Eleusine coracana (Indian finger millet) (Ragi).
OH NCBI_TaxID=29674; Eleusine indica (Goosegrass) (Cynosurus indicus).
OH NCBI_TaxID=4513; Hordeum vulgare (Barley).
OH NCBI_TaxID=59788; Megathyrsus maximus.
OH NCBI_TaxID=29709; Melinis repens (Natal redtop) (Rhynchelytrum repens).
OH NCBI_TaxID=4538; Oryza glaberrima (African rice).
OH NCBI_TaxID=4530; Oryza sativa (Rice).
OH NCBI_TaxID=158143; Paspalum conjugatum (Hilo grass).
OH NCBI_TaxID=147272; Paspalum notatum (Bahia grass).
OH NCBI_TaxID=173849; Paspalum scrobiculatum.
OH NCBI_TaxID=300125; Rottboellia cochinchinensis.
OH NCBI_TaxID=4547; Saccharum officinarum (Sugarcane).
OH NCBI_TaxID=192628; Setaria barbata.
OH NCBI_TaxID=4565; Triticum aestivum (Wheat).
OH NCBI_TaxID=4577; Zea mays (Maize).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6526009; DOI=10.1002/j.1460-2075.1984.tb02258.x;
RA Mullineaux P.M., Donson J., Morris-Krsinich B.A.M., Boulton M.I.,
RA Davies J.W.;
RT "The nucleotide sequence of maize streak virus DNA.";
RL EMBO J. 3:3063-3068(1984).
RN [2]
RP SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, DNA-BINDING, AND
RP MUTAGENESIS OF ARG-6; LYS-7; LYS-20 AND LYS-21.
RX PubMed=10517029; DOI=10.1094/mpmi.1999.12.10.894;
RA Liu H., Boulton M.I., Thomas C.L., Prior D.A.M., Oparka K.J., Davies J.W.;
RT "Maize streak virus coat protein is karyophyllic and facilitates nuclear
RT transport of viral DNA.";
RL Mol. Plant Microbe Interact. 12:894-900(1999).
RN [3]
RP INTERACTION WITH THE MOVEMENT PROTEIN.
RX PubMed=11125156; DOI=10.1099/0022-1317-82-1-35;
RA Liu H., Boulton M.I., Oparka K.J., Davies J.W.;
RT "Interaction of the movement and coat proteins of Maize streak virus:
RT implications for the transport of viral DNA.";
RL J. Gen. Virol. 82:35-44(2001).
CC -!- FUNCTION: Encapsidates the viral genome into characteristic twinned
CC ('geminate') particles. Binds the genomic viral ssDNA and shuttles it
CC into and out of the cell nucleus. Plays a role in protection of the
CC genome from degradation, virus acquisition and transmission by insect
CC vectors, infectivity, and systemic movement. The CP of monopartite
CC geminiviruses is absolutely essential for virus movement (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimer. Interacts with the movement protein (By
CC similarity). Binds to single-stranded and double-stranded viral DNA.
CC {ECO:0000250, ECO:0000269|PubMed:11125156}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus
CC {ECO:0000269|PubMed:10517029}. Note=It is actively transported into the
CC host cell nucleus. It may be exported out of the nucleus through a
CC nuclear export signal for cell-to-cell movement and spread (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the geminiviridae capsid protein family.
CC {ECO:0000305}.
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DR EMBL; X01633; CAA25788.1; -; Genomic_DNA.
DR PIR; A04173; VCCVSV.
DR SMR; P06448; -.
DR Proteomes; UP000007779; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.20; -; 1.
DR InterPro; IPR000143; Gemcoat_MSV.
DR InterPro; IPR000263; GV_A/BR1_coat.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF00844; Gemini_coat; 1.
DR PRINTS; PR00223; GEMCOATARBR1.
DR PRINTS; PR00226; GEMCOATMSV.
PE 1: Evidence at protein level;
KW Capsid protein; DNA-binding; Host nucleus; Reference proteome;
KW T=1 icosahedral capsid protein; Viral penetration into host nucleus;
KW Virion; Virus entry into host cell.
FT CHAIN 1..244
FT /note="Capsid protein"
FT /id="PRO_0000222186"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1..24
FT /note="Bipartite nuclear localization signal"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 6
FT /note="R->T: Abolishes nuclear localization; when
FT associated with N-7; N-20 and N-21."
FT /evidence="ECO:0000269|PubMed:10517029"
FT MUTAGEN 7
FT /note="K->N: Abolishes nuclear localization; when
FT associated with T-6; N-20 and N-21."
FT /evidence="ECO:0000269|PubMed:10517029"
FT MUTAGEN 20
FT /note="K->N: Abolishes nuclear localization; when
FT associated with T-6; N-7 and N-21."
FT /evidence="ECO:0000269|PubMed:10517029"
FT MUTAGEN 21
FT /note="K->N: Abolishes nuclear localization; when
FT associated with T-6; N-7 and N-20."
FT /evidence="ECO:0000269|PubMed:10517029"
SQ SEQUENCE 244 AA; 26969 MW; 800FDD501F4C0B7D CRC64;
MSTSKRKRGD DSNWSKRVTK KKPSSAGLKR AGSKADRPSL QIQTLQHAGT TMITVPSGGV
CDLINTYARG SDEGNRHTSE TLTYKIAIDY HFVADAAACR YSNTGTGVMW LVYDTTPGGQ
APTPQTIFAY PDTLKAWPAT WKVSRELCHR FVVKRRWLFN METDGRIGSD IPPSNASWKP
CKRNIYFHKF TSGLGVRTQW KNVTDGGVGA IQRGALYMVI APGNGLTFTA HGQTRLYFKS
VGNQ
