ID   Y1586_HAEIN             Reviewed;         519 AA.
AC   P44263;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Uncharacterized protein HI_1586;
GN   OrderedLocusNames=HI_1586;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC23234.1; -; Genomic_DNA.
DR   PIR; C64037; C64037.
DR   RefSeq; NP_439731.1; NC_000907.1.
DR   AlphaFoldDB; P44263; -.
DR   STRING; 71421.HI_1586; -.
DR   EnsemblBacteria; AAC23234; AAC23234; HI_1586.
DR   KEGG; hin:HI_1586; -.
DR   PATRIC; fig|71421.8.peg.1660; -.
DR   eggNOG; COG1757; Bacteria.
DR   HOGENOM; CLU_018751_1_0_6; -.
DR   OMA; YGDHTSP; -.
DR   PhylomeDB; P44263; -.
DR   BioCyc; HINF71421:G1GJ1-1602-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR   Pfam; PF03553; Na_H_antiporter; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..519
FT                   /note="Uncharacterized protein HI_1586"
FT                   /id="PRO_0000078093"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        475..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        496..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   519 AA;  55499 MW;  0EBF908C0454E4B1 CRC64;
     MLSVLSINYR YYLMELIDFS SSVWSIVPAL LAIILAIATR RVLVSLSAGI IIGSLMLSDW
     QIGSAFNYLV KNVVSLVYAD GEINSNMNIV LFLLLLGVLT ALLTVSGSNR AFAEWAQSRI
     KGRRGAKLLA ASLVFVTFID DYFHSLAVGA IARPVTDRFK VSRAKLAYIL DSTAAPMCVM
     MPVSSWGAYI ITLIGGLLAT YSITEYTPIG AFVAMSSMNF YAIFSIIMVF FVAYFSFDIA
     SMVRHEKLAL KNTEDQLEEE TGTKGQVRNL ILPILVLIIA TVSMMIYTGA EALAADGKVF
     SVLGTFENTV VGTSLVVGGF CSIIISTLLI ILDRQVSVPE YVRSWIVGIK SMSGAIAILF
     FAWTINKIVG DMQTGKYLSS LVSGNIPMQF LPVILFVLGA AMAFSTGTSW GTFGIMLPIA
     AAMAANAAPE LLLPCLSAVM AGAVCGDHCS PVSDTTILSS TGAKCNHIDH VTTQLPYAAT
     VATATSIGYI VVGFTYSGLA GFAATAVSLI VIIFAVKKR