ID   Y1592_MYCTU             Reviewed;         446 AA.
AC   P9WK89; L0T740; O06598; Q8VK00;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Probable inactive lipase Rv1592c;
GN   OrderedLocusNames=Rv1592c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION BY HYPOXIA.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11416222; DOI=10.1073/pnas.121172498;
RA   Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA   Schoolnik G.K.;
RT   "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT   encoding alpha -crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN   [3]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: A possible member of the dormancy regulon. Induced in
CC       response to reduced oxygen tension (hypoxia). It is hoped that this
CC       regulon will give insight into the latent, or dormant phase of
CC       infection. {ECO:0000269|PubMed:11416222}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Although related to the lipase family, lacks the conserved His
CC       active site at position 344 which is replaced by a Gln residue,
CC       suggesting it is inactive. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44356.1; -; Genomic_DNA.
DR   PIR; B70543; B70543.
DR   RefSeq; NP_216108.1; NC_000962.3.
DR   RefSeq; WP_003906637.1; NZ_NVQJ01000016.1.
DR   AlphaFoldDB; P9WK89; -.
DR   SMR; P9WK89; -.
DR   STRING; 83332.Rv1592c; -.
DR   ESTHER; myctu-MT1628; Fungal-Bact_LIP.
DR   PaxDb; P9WK89; -.
DR   DNASU; 886287; -.
DR   GeneID; 886287; -.
DR   KEGG; mtu:Rv1592c; -.
DR   TubercuList; Rv1592c; -.
DR   eggNOG; COG1073; Bacteria.
DR   OMA; SAWAAEM; -.
DR   PhylomeDB; P9WK89; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005152; Lipase_secreted.
DR   PANTHER; PTHR34853; PTHR34853; 1.
DR   Pfam; PF03583; LIP; 1.
DR   PIRSF; PIRSF029171; Esterase_LipA; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..446
FT                   /note="Probable inactive lipase Rv1592c"
FT                   /id="PRO_0000392687"
SQ   SEQUENCE   446 AA;  48043 MW;  C93BB8FB005C7518 CRC64;
     MVEPGNLAGA TGAEWIGRPP HEELQRKVRP LLPSDDPFYF PPAGYQHAVP GTVLRSRDVE
     LAFMGLIPQP VTATQLLYRT TNMYGNPEAT VTTVIVPAEL APGQTCPLLS YQCAIDAMSS
     RCFPSYALRR RAKALGSLTQ MELLMISAAL AEGWAVSVPD HEGPKGLWGS PYEPGYRVLD
     GIRAALNSER VGLSPATPIG LWGYSGGGLA SAWAAEACGE YAPDLDIVGA VLGSPVGDLG
     HTFRRLNGTL LAGLPALVVA ALQHSYPGLA RVIKEHANDE GRQLLEQLTE MTTVDAVIRM
     AGRDMGDFLD EPLEDILSTP EISHVFGDTK LGSAVPTPPV LIVQAVHDYL IDVSDIDALA
     DSYTAGGANV TYHRDLFSEH VSLHPLSAPM TLRWLTDRFA GKPLTDHRVR TTWPTIFNPM
     TYAGMARLAV IAAKVITGRK LSRRPL