ID   Y1592_SYNY3             Reviewed;         291 AA.
AC   P72970;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase slr1592;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=slr1592;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; BA000022; BAA16988.1; -; Genomic_DNA.
DR   PIR; S74948; S74948.
DR   AlphaFoldDB; P72970; -.
DR   SMR; P72970; -.
DR   IntAct; P72970; 2.
DR   STRING; 1148.1652063; -.
DR   PaxDb; P72970; -.
DR   EnsemblBacteria; BAA16988; BAA16988; BAA16988.
DR   KEGG; syn:slr1592; -.
DR   eggNOG; COG0564; Bacteria.
DR   InParanoid; P72970; -.
DR   OMA; IGKIPHP; -.
DR   PhylomeDB; P72970; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..291
FT                   /note="Uncharacterized RNA pseudouridine synthase slr1592"
FT                   /id="PRO_0000162746"
SQ   SEQUENCE   291 AA;  33096 MW;  D93D79A569920AE8 CRC64;
     MLDFYSQRYL HSERQAWQER IEQGQIEVDG KTVDPTYPLQ AGQTLTYWRS PWVEPEVPLQ
     LSVLHRDEDL WAIDKPSGLP VLPGGDFVYH TVLEQLKIQY PQESLFPLHR LGTGTSGLLL
     LGRSTLGRRE LSRQFREHIC RKIYRTVIGP CDLPEKFECH QAIGKIPYPQ LGYIYAASSH
     GKPAQSYGRI LARSPEKTWL EVEIRTGRPH QIRIHLASLG YPLLGDRLYG PGGVPINCRT
     ARPSDGGYTL HSYQLGFLHL HTQQAIKLTA PLPPELITPE VKTIALETEK H