ID   CAPSD_OASV1             Reviewed;         762 AA.
AC   Q9JH65;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   02-JUN-2021, entry version 53.
DE   RecName: Full=Capsid polyprotein VP90;
GN   ORFNames=ORF2;
OS   Ovine astrovirus 1 (OAstV-1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC   Stellavirales; Astroviridae; Mamastrovirus.
OX   NCBI_TaxID=1239577;
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12573498; DOI=10.1016/s0168-1702(02)00269-1;
RA   Jonassen C.M., Jonassen T.O., Sveen T.M., Grinde B.;
RT   "Complete genomic sequences of astroviruses from sheep and turkey:
RT   comparison with related viruses.";
RL   Virus Res. 91:195-201(2003).
CC   -!- FUNCTION: The capsid polyprotein VP90 self-assembles and undergoes a
CC       proteolytic cleavage by host caspases to yield the VP70 virions. This
CC       immature virion is composed of 180 VP70 subunits with 90 dimeric spikes
CC       and displays a T=3 icosahedral symmetry. The mature virion is obtained
CC       by further cleavages resulting in three structural proteins VP25, VP27
CC       and VP34. This forms contains only 30 spikes located on the icosahedral
CC       2-fold axes. Plays a role in the attachment to target host cell. This
CC       attachment induces virion internalization through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- PTM: Specific enzymatic cleavages in vivo yield mature protein(s). VP90
CC       undergoes a cascade of proteolytic cleavages presumably mediated by
CC       host caspases and extracellular proteases (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the astroviridae capsid polyprotein family.
CC       {ECO:0000305}.
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DR   EMBL; Y15937; CAB95004.1; -; Genomic_RNA.
DR   RefSeq; NP_059946.1; NC_002469.1.
DR   SMR; Q9JH65; -.
DR   GeneID; 1449588; -.
DR   KEGG; vg:1449588; -.
DR   Proteomes; UP000007786; Genome.
DR   GO; GO:0039617; C:T=3 icosahedral viral capsid; ISS:UniProtKB.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; ISS:UniProtKB.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR004337; Capsid_astroviral.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF03115; Astro_capsid_N; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   T=3 icosahedral capsid protein; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..762
FT                   /note="Capsid polyprotein VP90"
FT                   /id="PRO_0000320240"
FT   REGION          25..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..56
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   762 AA;  82366 MW;  10869898151CF511 CRC64;
     MAEKPQQKAV ASAAKQLAKE VVKLDKITKS NGKQHPQKNV PARKWRPRQA KPNNRRVTHK
     IKRELHKQGL EGPASRFRVT VSATIGKVGP NKEQGPELQI ATFLHPSLVK EPNDGSNFGP
     LQAAAAQWGL WRISDLEVRF TPLVGSSAVT GSVTRASLNL TQSPGATSWG GLGARKHLDV
     PTGVSKVWKL RRGDLTGPRQ TWWVTDTNEE GGQSCGPMLE VHGLGKTTST YKDSDWTGDL
     FIVELHGTWE FSNYNAKPAL GMLERVTDQT NVELGVDTEG QITMTIPENS PMARHMGERF
     ERASASNASS VGETIWQIVD EGAGLASSVA PAPFGWLIKG GWWFVKKILG RAANAGSQYL
     VYASLADAQN GKPAMSTSRG YVREVKQTIL SSTQLNAPNT GPGASQPALA AYEMFPYFPH
     GEPAVGQPFY LMSTVSTGVY REAMPVWVKY NYPGAPSNQA PFEVTIGQTT YQAQTYFKLT
     EPVAYGADIP EVTSEVKPAL NGWYTLDTLP AIGTFQAIFT LPGTKSKYGD VVAASHFSIT
     PQLMLVAYLV RVTTALPNAL RGSPWSDNAD NSILYYTPLV NAYAAATSDA NPIQFTPNRA
     CVSECRSHCG HPTIVAADVG EYILALVWCR GNGFSAGVIN SYGALADTSF NLDSLRADSN
     GVMTLLNRAV PYSSLCALRM TRGVPPTSDD ELVARILGQL QTRLKFAAGS GSSSEDDLSD
     DDDFECLRST PLQQIYEGVR GLRGHAEAVA VVKSLQSRGH AE