ID   Y1603_MYCS2             Reviewed;         375 AA.
AC   A0QSU4; I7FYG7;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Uncharacterized oxidoreductase MSMEG_1603/MSMEI_1564;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MSMEG_1603, MSMEI_1564;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
RN   [4]
RP   PUPYLATION AT LYS-99, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=20094657; DOI=10.1039/b916104j;
RA   Watrous J., Burns K., Liu W.T., Patel A., Hook V., Bafna V.,
RA   Barry C.E. III, Bark S., Dorrestein P.C.;
RT   "Expansion of the mycobacterial 'PUPylome'.";
RL   Mol. Biosyst. 6:376-385(2010).
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AFP38037.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000480; ABK75325.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP38037.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011727767.1; NC_018289.1.
DR   RefSeq; YP_885982.1; NC_008596.1.
DR   AlphaFoldDB; A0QSU4; -.
DR   SMR; A0QSU4; -.
DR   STRING; 246196.MSMEI_1564; -.
DR   PRIDE; A0QSU4; -.
DR   EnsemblBacteria; ABK75325; ABK75325; MSMEG_1603.
DR   EnsemblBacteria; AFP38037; AFP38037; MSMEI_1564.
DR   GeneID; 66733055; -.
DR   KEGG; msg:MSMEI_1564; -.
DR   KEGG; msm:MSMEG_1603; -.
DR   PATRIC; fig|246196.19.peg.1589; -.
DR   eggNOG; COG0516; Bacteria.
DR   OMA; AARRDYM; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0003938; F:IMP dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR   CDD; cd00381; IMPDH; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR005992; IMP_DH-rel2.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   PANTHER; PTHR11911; PTHR11911; 1.
DR   PANTHER; PTHR11911:SF85; PTHR11911:SF85; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   TIGRFAMs; TIGR01304; IMP_DH_rel_2; 1.
PE   1: Evidence at protein level;
KW   Isopeptide bond; NAD; Oxidoreductase; Reference proteome; Ubl conjugation.
FT   CHAIN           1..375
FT                   /note="Uncharacterized oxidoreductase
FT                   MSMEG_1603/MSMEI_1564"
FT                   /id="PRO_0000396107"
FT   CROSSLNK        99
FT                   /note="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain
FT                   with Q-Cter in protein Pup)"
FT                   /evidence="ECO:0000269|PubMed:20094657"
SQ   SEQUENCE   375 AA;  39006 MW;  A126754CAF940347 CRC64;
     MVEIGMGRTA RRTYELEDVT IVPSRRTRSS KDVSTAWQLD AYRFEIPVIA HPTDALVSPE
     FAIEMGRLGG LGVLNGEGLI GRHADVEEKI AQVVEVAAKE PEPSAAIRLL QQLHAAPLDP
     DLLGAAVARI REAGVTTAVR VSPQNAQALT PTLVAAGIDL LVIQGTIISA ERVASDGEPL
     NLKTFISELD VPVVAGGVLD HRTALHLMRT GAAGVIVGYG STSGVTTSDE VLGISVPMAT
     AIADAAAARR EYLDETGGRY VHVLADGDIH SSGDLAKAIA CGADAVVLGT PLATSAEALG
     NGWFWPAAAA HPSLPRGALL QVALGERPSL EQVLTGPSDD PFGSLNLVGG LRRSMAKAGY
     CDLKEFQKVG LTVGS