ID   Y161_HELPJ              Reviewed;         299 AA.
AC   Q9ZMQ7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Putative peptidyl-prolyl cis-trans isomerase jhp_0161;
DE            Short=PPIase jhp_0161;
DE            EC=5.2.1.8;
DE   AltName: Full=Rotamase jhp_0161;
DE   Flags: Precursor;
GN   OrderedLocusNames=jhp_0161;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
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DR   EMBL; AE001439; AAD05744.1; -; Genomic_DNA.
DR   PIR; B71967; B71967.
DR   RefSeq; WP_000739442.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZMQ7; -.
DR   SMR; Q9ZMQ7; -.
DR   STRING; 85963.jhp_0161; -.
DR   EnsemblBacteria; AAD05744; AAD05744; jhp_0161.
DR   GeneID; 66521425; -.
DR   KEGG; hpj:jhp_0161; -.
DR   PATRIC; fig|85963.30.peg.861; -.
DR   eggNOG; COG0760; Bacteria.
DR   OMA; YEQAKPT; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR000297; PPIase_PpiC.
DR   InterPro; IPR023058; PPIase_PpiC_CS.
DR   Pfam; PF00639; Rotamase; 1.
DR   PROSITE; PS01096; PPIC_PPIASE_1; 1.
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1.
PE   3: Inferred from homology;
KW   Isomerase; Rotamase; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..299
FT                   /note="Putative peptidyl-prolyl cis-trans isomerase
FT                   jhp_0161"
FT                   /id="PRO_0000025548"
FT   DOMAIN          154..253
FT                   /note="PpiC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
SQ   SEQUENCE   299 AA;  34040 MW;  9C037B1CD1110143 CRC64;
     MKKNILNLAL VGALSASFLM AKPAHNANNS THNTKETTDA SAGVLATVDG RPITKSDFDM
     IKQRNPNFDF DKLKEKEKEA LIEQAIRTAL VENEAKAEKL NQTPEFKAMM EAVKKQALVE
     FWAKKQAEEV KKIQIPEKEM QDFYNANKDQ LFVKQEAHAR HILVKTEDEA KRIISEIDKQ
     PKAKKEAKFI ELANRDTIDP NSKNAQNGGD LGKFQKNQMA PDFSKAAFAL TPGDYTKTPV
     KTEFGYHIIY LISKDSPVTY TYEQAKPTIK GMLQEKLFQE RMNQRIEELR KHAKIVINK