ID   Y1622_MYCPA             Reviewed;         302 AA.
AC   Q73ZI1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_1622c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_1622c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS03939.1; -; Genomic_DNA.
DR   RefSeq; WP_003876602.1; NC_002944.2.
DR   AlphaFoldDB; Q73ZI1; -.
DR   SMR; Q73ZI1; -.
DR   STRING; 262316.MAP_1622c; -.
DR   EnsemblBacteria; AAS03939; AAS03939; MAP_1622c.
DR   KEGG; mpa:MAP_1622c; -.
DR   PATRIC; fig|262316.17.peg.1715; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; GSAASMW; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..302
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_1622c"
FT                   /id="PRO_0000361176"
FT   BINDING         129
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         158..159
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   302 AA;  32705 MW;  A4FEF73139D5CD73 CRC64;
     MTTPQFGSQR SDDDNWDIVS SVGYTALLVA GWRALHAVSP RPLVRDDYAK TFIAASGDPY
     LTGVLANPGT SEDELAFPRL YGAQTRFFDD FFDAAGAAGI RQAVIIAAGL DSRAYRLEWP
     PATTVFEVDL AKVLEFKARV LGEQGAVPKA RRVEVAADLR ADWSRPLEAA GFDVESPSAW
     SVEGLLPYLT DEAQHALFTR ISGLSAPGSR IAIGALGSRL DHDQLHALEE SHPGVDVSGN
     VDFSALTYEP QSDPAEWLAA HGWVVDPVRN TLDLQAGYGM TPPEVDVKID GFMRSQYITA
     AR