Y1624_PSEAE
ID Y1624_PSEAE Reviewed; 268 AA.
AC Q9I398;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Uncharacterized protein PA1624 {ECO:0000305};
DE Flags: Precursor;
GN OrderedLocusNames=PA1624 {ECO:0000312|EMBL:AAG05013.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2] {ECO:0007744|PDB:6TD9}
RP X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 19-268, SUBUNIT, SUBCELLULAR
RP LOCATION, DOMAIN, AND DISULFIDE BOND.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=33263573; DOI=10.1107/s2053230x20014612;
RA Feiler C.G., Weiss M.S., Blankenfeldt W.;
RT "The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa
RT folds into a unique two-domain structure.";
RL Acta Crystallogr. F Struct. Biol. Commun. 76:609-615(2020).
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:33263573}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:33263573}.
CC -!- DOMAIN: Folds into a unique two-domain structure. The structure
CC consists of two domains, domains 1 and 2, which are connected via a
CC long linker. The interior of the C-terminal domain is not optimally
CC packed, leaving a cavity lined by hydrophobic residues unoccupied. This
CC cavity may sequester a hydrophobic ligand.
CC {ECO:0000269|PubMed:33263573}.
CC -!- MISCELLANEOUS: Was identified as a potential drug target.
CC {ECO:0000305|PubMed:33263573}.
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DR EMBL; AE004091; AAG05013.1; -; Genomic_DNA.
DR PIR; C83442; C83442.
DR RefSeq; NP_250315.1; NC_002516.2.
DR RefSeq; WP_003097863.1; NZ_QZGE01000003.1.
DR PDB; 6TD9; X-ray; 1.96 A; A/B=19-268.
DR PDBsum; 6TD9; -.
DR AlphaFoldDB; Q9I398; -.
DR SMR; Q9I398; -.
DR STRING; 287.DR97_265; -.
DR PaxDb; Q9I398; -.
DR PRIDE; Q9I398; -.
DR DNASU; 881888; -.
DR EnsemblBacteria; AAG05013; AAG05013; PA1624.
DR GeneID; 881888; -.
DR KEGG; pae:PA1624; -.
DR PATRIC; fig|208964.12.peg.1684; -.
DR PseudoCAP; PA1624; -.
DR HOGENOM; CLU_080669_0_0_6; -.
DR OMA; AYLHVEQ; -.
DR PhylomeDB; Q9I398; -.
DR BioCyc; PAER208964:G1FZ6-1654-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR InterPro; IPR032608; DUF4892.
DR Pfam; PF16234; DUF4892; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..268
FT /note="Uncharacterized protein PA1624"
FT /evidence="ECO:0000255"
FT /id="PRO_5004327441"
FT REGION 24..184
FT /note="Domain 1"
FT /evidence="ECO:0000269|PubMed:33263573"
FT REGION 185..268
FT /note="Domain 2"
FT /evidence="ECO:0000269|PubMed:33263573"
FT DISULFID 110..115
FT /evidence="ECO:0000269|PubMed:33263573,
FT ECO:0007744|PDB:6TD9"
FT STRAND 37..54
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 56..59
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 62..81
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 88..101
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 105..111
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 112..115
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 118..123
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 129..131
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 135..137
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 139..144
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 152..160
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 166..177
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 186..196
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 197..201
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 210..222
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 223..225
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 227..232
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 235..244
FT /evidence="ECO:0007829|PDB:6TD9"
FT HELIX 249..251
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 252..254
FT /evidence="ECO:0007829|PDB:6TD9"
FT STRAND 260..267
FT /evidence="ECO:0007829|PDB:6TD9"
SQ SEQUENCE 268 AA; 29534 MW; BC9156036F943C9D CRC64;
MRGFLLLSLG VFSFSALAAD LPGSHDLDIL PRFPRAEIVD FRQAPSEERI YPLGAISRIS
GRLRMEGEVR AEGELTALTY RLPPEHSSQE AFAAARTALL KADATPLFWC ERRDCGSSSL
LANAVFGNAK LYGPDEQQAY LLVRLAAPQE NSLVAVYSIT RGNRRAYLQA EELKADAPLA
ELLPSPATLL RLLKANGELT LSHVPAEPAG SWLELLVRTL RLDTGVRVEL SGKHAQEWRD
ALRGQGVLNS RMELGQSEVE GLHLNWLR
