Y1634_ARATH
ID Y1634_ARATH Reviewed; 664 AA.
AC C0LGH8; Q8GY10; Q9SH29;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g63430;
DE EC=2.7.11.1;
DE Flags: Precursor;
GN OrderedLocusNames=At1g63430; ORFNames=F2K11.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT like protein kinase genes in Arabidopsis thaliana.";
RL BMC Genomics 11:19-19(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- INTERACTION:
CC C0LGH8; Q0WVM4: At2g23950; NbExp=3; IntAct=EBI-20657656, EBI-20655099;
CC C0LGH8; Q9M8T0: At3g02880; NbExp=3; IntAct=EBI-20657656, EBI-1238677;
CC C0LGH8; Q9SUQ3: At4g23740; NbExp=3; IntAct=EBI-20657656, EBI-16912451;
CC C0LGH8; C0LGR9: At4g31250; NbExp=2; IntAct=EBI-20657656, EBI-16955262;
CC C0LGH8; Q9FMD7: At5g16590; NbExp=3; IntAct=EBI-20657656, EBI-16903983;
CC C0LGH8; C0LGU5: At5g45780; NbExp=3; IntAct=EBI-20657656, EBI-16964970;
CC C0LGH8; Q8W4S5: At5g63710; NbExp=3; IntAct=EBI-20657656, EBI-16934827;
CC C0LGH8; A0A178UFM8: AXX17_At5g50380; NbExp=3; IntAct=EBI-20657656, EBI-20653342;
CC C0LGH8; O22138: LRR-RLK; NbExp=4; IntAct=EBI-20657656, EBI-16946020;
CC C0LGH8; Q9LJY0: PRK4; NbExp=2; IntAct=EBI-20657656, EBI-16914444;
CC C0LGH8; Q9LVI6: RLK902; NbExp=4; IntAct=EBI-20657656, EBI-1626936;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=C0LGH8-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF19706.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC008047; AAF19706.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34098.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58821.1; -; Genomic_DNA.
DR EMBL; AK117932; BAC42570.1; -; mRNA.
DR EMBL; FJ708668; ACN59263.1; -; mRNA.
DR RefSeq; NP_001321232.1; NM_001334093.1. [C0LGH8-1]
DR RefSeq; NP_176532.2; NM_105022.3. [C0LGH8-1]
DR AlphaFoldDB; C0LGH8; -.
DR SMR; C0LGH8; -.
DR BioGRID; 27870; 21.
DR IntAct; C0LGH8; 31.
DR STRING; 3702.AT1G63430.2; -.
DR PaxDb; C0LGH8; -.
DR PRIDE; C0LGH8; -.
DR ProteomicsDB; 242394; -. [C0LGH8-1]
DR EnsemblPlants; AT1G63430.1; AT1G63430.1; AT1G63430. [C0LGH8-1]
DR EnsemblPlants; AT1G63430.3; AT1G63430.3; AT1G63430. [C0LGH8-1]
DR GeneID; 842649; -.
DR Gramene; AT1G63430.1; AT1G63430.1; AT1G63430. [C0LGH8-1]
DR Gramene; AT1G63430.3; AT1G63430.3; AT1G63430. [C0LGH8-1]
DR KEGG; ath:AT1G63430; -.
DR Araport; AT1G63430; -.
DR eggNOG; ENOG502QS4J; Eukaryota.
DR HOGENOM; CLU_000288_92_4_1; -.
DR InParanoid; C0LGH8; -.
DR OMA; HEKAPGR; -.
DR PhylomeDB; C0LGH8; -.
DR PRO; PR:C0LGH8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; C0LGH8; baseline and differential.
DR Genevisible; C0LGH8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Cell membrane; Glycoprotein; Kinase;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Receptor;
KW Reference proteome; Repeat; Serine/threonine-protein kinase; Signal;
KW Transferase; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..664
FT /note="Probable LRR receptor-like serine/threonine-protein
FT kinase At1g63430"
FT /id="PRO_0000387538"
FT TOPO_DOM 23..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..664
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 94..116
FT /note="LRR 1"
FT REPEAT 118..140
FT /note="LRR 2"
FT REPEAT 142..165
FT /note="LRR 3"
FT REPEAT 166..178
FT /note="LRR 4"
FT DOMAIN 360..642
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 50
FT /note="N -> D (in Ref. 3; BAC42570)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 664 AA; 73910 MW; 8520F165DA7CB366 CRC64;
MRSKYFCSLA LVLGLFFVSC DGFASNEVQA LRRFKEAIYE DPLLVMSNWN DPNSDPCDWT
GIYCSPSKDH VIKINISASS IKGFLAPELG QITYLQELIL HGNILIGTIP KEIGNLKNLK
ILDLGNNHLM GPIPAEIGSL SGIMIINLQS NGLTGKLPAE LGNLKYLREL HIDRNRLQGS
LLVAGASGYQ SKVYSSNSSA NIAGLCKSLK VADFSYNFFV GNIPKCLENL PRTSFQGNCM
QNKDLKHRSS SQCANAQLVK THGSPSAAPK HQSAQMVAKH HRASKPKWLL ALEIVTGSMV
GLLLLVALFS AVHRWNNRST LIIPWKKSSS EKEKFTVYVD SEMLKDVSRL TRQELEVACE
DFSNIIGLSA DSQIYKGTLK GGSEIAVISL CVKEEDWTGY LELYFQREVA DLARLNHENT
AKLLGYCKEI SPFTRMLVFE YASNGTLYEH LHYGEAALVS WARRMKIVIG IARGLKYLHM
ELDPPFTISE LSSNAIYLTE DFTPKLVDFE CWKTILARSE KNLRNISSQG SICVLPNGME
SRYLDVSGNI YAFGILLLEI VSGRPPYCKD KGFLIEWAKE FLEAPEAMSG LVDPELKHFN
QEDLETVCEV ASQCLNRDPT NNNNNHNKPS VQELCETLES RISLSISAEL RSSSLAWAEL
ALDS
