ID   Y1634_MYCTO             Reviewed;         471 AA.
AC   P9WJX2; L0TA74; O06151; Q7D886;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Probable multidrug-efflux transporter MT1670;
GN   OrderedLocusNames=MT1670;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Could be involved in fluoroquinolones efflux. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45940.1; -; Genomic_DNA.
DR   PIR; H70559; H70559.
DR   RefSeq; WP_003898954.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJX2; -.
DR   SMR; P9WJX2; -.
DR   EnsemblBacteria; AAK45940; AAK45940; MT1670.
DR   KEGG; mtc:MT1670; -.
DR   PATRIC; fig|83331.31.peg.1795; -.
DR   HOGENOM; CLU_000960_2_6_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..471
FT                   /note="Probable multidrug-efflux transporter MT1670"
FT                   /id="PRO_0000427755"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  47713 MW;  C9EF4D9BF517ECB0 CRC64;
     MTETASETGS WRELLSRYLG TSIVLAGGVA LYATNEFLTI SLLPSTIADI GGSRLYAWVT
     TLYLVGSVVA ATTVNTMLLR VGARSSYLMG LAVFGLASLV CAAAPSMQIL VAGRTLQGIA
     GGLLAGLGYA LINSTLPKSL WTRGSALVSA MWGVATLIGP ATGGLFAQLG LWRWAFGVMT
     LLTALMAMLV PVALGAGGVG PGGETPVGST HKVPVWSLLL MGAAALAISV AALPNYLVQT
     AGLLAAAALL VAVFVVVDWR IHAAVLPPSV FGSGPLKWIY LTMSVQMIAA MVDTYVPLFG
     QRLGHLTPVA AGFLGAALAV GWTVGEVASA SLNSARVIGH VVAAAPLVMA SGLALGAVTQ
     RADAPVGIIA LWALALLIIG TGIGIAWPHL TVRAMDSVAD PAESSAAAAA INVVQLISGA
     FGAGLAGVVV NTAKGGEVAA ARGLYMAFTV LAAAGVIASY QATHRDRRLP R