Y1634_MYCTU
ID Y1634_MYCTU Reviewed; 471 AA.
AC P9WJX3; L0TA74; O06151; Q7D886;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Probable multidrug-efflux transporter Rv1634;
GN OrderedLocusNames=Rv1634;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP FUNCTION IN FLUOROQUINOLONES EFFLUX.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=12520088;
RA De Rossi E., Arrigo P., Bellinzoni M., Silva P.A., Martin C., Ainsa J.A.,
RA Guglierame P., Riccardi G.;
RT "The multidrug transporters belonging to major facilitator superfamily in
RT Mycobacterium tuberculosis.";
RL Mol. Med. 8:714-724(2002).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Could be involved in fluoroquinolones efflux.
CC {ECO:0000269|PubMed:12520088}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP44398.1; -; Genomic_DNA.
DR PIR; H70559; H70559.
DR RefSeq; NP_216150.1; NC_000962.3.
DR RefSeq; WP_003898954.1; NZ_NVQJ01000016.1.
DR AlphaFoldDB; P9WJX3; -.
DR SMR; P9WJX3; -.
DR STRING; 83332.Rv1634; -.
DR PaxDb; P9WJX3; -.
DR DNASU; 885115; -.
DR GeneID; 885115; -.
DR KEGG; mtu:Rv1634; -.
DR TubercuList; Rv1634; -.
DR eggNOG; COG2814; Bacteria.
DR OMA; MWGIATL; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IMP:MTBBASE.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IMP:MTBBASE.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Antibiotic resistance; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..471
FT /note="Probable multidrug-efflux transporter Rv1634"
FT /id="PRO_0000390683"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 471 AA; 47713 MW; C9EF4D9BF517ECB0 CRC64;
MTETASETGS WRELLSRYLG TSIVLAGGVA LYATNEFLTI SLLPSTIADI GGSRLYAWVT
TLYLVGSVVA ATTVNTMLLR VGARSSYLMG LAVFGLASLV CAAAPSMQIL VAGRTLQGIA
GGLLAGLGYA LINSTLPKSL WTRGSALVSA MWGVATLIGP ATGGLFAQLG LWRWAFGVMT
LLTALMAMLV PVALGAGGVG PGGETPVGST HKVPVWSLLL MGAAALAISV AALPNYLVQT
AGLLAAAALL VAVFVVVDWR IHAAVLPPSV FGSGPLKWIY LTMSVQMIAA MVDTYVPLFG
QRLGHLTPVA AGFLGAALAV GWTVGEVASA SLNSARVIGH VVAAAPLVMA SGLALGAVTQ
RADAPVGIIA LWALALLIIG TGIGIAWPHL TVRAMDSVAD PAESSAAAAA INVVQLISGA
FGAGLAGVVV NTAKGGEVAA ARGLYMAFTV LAAAGVIASY QATHRDRRLP R
