ID   CAPSD_PICV              Reviewed;         273 AA.
AC   Q9IG42;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Probable capsid protein;
GN   Name=Cap;
OS   Pigeon circovirus (PiCV) (Columbid circovirus).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Cirlivirales; Circoviridae; Circovirus.
OX   NCBI_TaxID=126070;
OH   NCBI_TaxID=8932; Columba livia (Rock dove).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11205099; DOI=10.1007/s007050070002;
RA   Mankertz A., Hattermann K., Ehlers B., Soike D.;
RT   "Cloning and sequencing of columbid circovirus (coCV), a new circovirus
RT   from pigeons.";
RL   Arch. Virol. 145:2469-2479(2000).
CC   -!- FUNCTION: Self-assembles to form the virion icosahedral capsid with a
CC       T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows
CC       the virus to be very stable in the environment and resistant to some
CC       disinfectants, including detergents. Essential for the initial
CC       attachment to heparan sulfate moieties and chondroitin sulfate B of the
CC       host cell surface proteoglycans. After attachment, the virus is
CC       endocytosed and traffics to the nucleus. The capsid protein binds and
CC       transports the viral genome and Rep across the nuclear envelope (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Assembles in the nucleus, presumably in an
CC       immature form, then migrates to the cytoplasm once assembled as mature
CC       virion. Interacts with Rep; this interaction relocates Rep into the
CC       nucleus (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the circoviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF252610; AAF74197.1; -; Genomic_DNA.
DR   RefSeq; NP_059530.1; NC_002361.1.
DR   SMR; Q9IG42; -.
DR   GeneID; 1460802; -.
DR   KEGG; vg:1460802; -.
DR   Proteomes; UP000000473; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:InterPro.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.950; -; 1.
DR   InterPro; IPR003383; Circovirus_capsid.
DR   InterPro; IPR038652; Circovirus_capsid_sf.
DR   Pfam; PF02443; Circo_capsid; 1.
PE   3: Inferred from homology;
KW   Capsid protein; DNA-binding; Host nucleus; Host-virus interaction;
KW   Reference proteome; T=1 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Viral penetration into host nucleus; Virion; Virus endocytosis by host;
KW   Virus entry into host cell.
FT   CHAIN           1..273
FT                   /note="Probable capsid protein"
FT                   /id="PRO_0000319851"
FT   REGION          1..31
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          7..35
FT                   /note="Nuclear localization signals"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   273 AA;  31960 MW;  A6081D7732B5DB47 CRC64;
     MRRRRFRRRR APIRRRRIRR RRTRLSRNIR GHRRSSRIYY FRLRRKDKIT LTQATNDFKF
     GTGIFTFKLA DVLTVGLNAP TLKVPFEDYQ IALVKVEMRP LGVDITTWKG FGHTVPMYDA
     RLKTFQGQVD LGDDPLMDFD GARKWDLRKG FKRLIRPRPQ LTIADLATAN QSAATWFSGR
     NQWIPLQVSG NSLFPQKVNH YGLAFSYLQP QPDPMYYECE VTFYVKFRQF AWTTLNVPPT
     PNIEGMELMH ICNGDCNQCF ADALDPDSAV DSE