ID   Y1645_NEIMB             Reviewed;         446 AA.
AC   Q9JYD0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Uncharacterized membrane protein NMB1645;
GN   OrderedLocusNames=NMB1645;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17038831; DOI=10.4161/hv.1.2.1651;
RA   Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.;
RT   "Characterization of the protein content of a meningococcal outer membrane
RT   vesicle vaccine by polyacrylamide gel electrophoresis and mass
RT   spectrometry.";
RL   Hum. Vaccin. 1:80-84(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Present in outer membrane vesicle formulations which are
CC       used as vaccines in human.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE002098; AAF41994.1; -; Genomic_DNA.
DR   PIR; D81058; D81058.
DR   RefSeq; NP_274650.1; NC_003112.2.
DR   RefSeq; WP_002224998.1; NC_003112.2.
DR   AlphaFoldDB; Q9JYD0; -.
DR   STRING; 122586.NMB1645; -.
DR   PaxDb; Q9JYD0; -.
DR   EnsemblBacteria; AAF41994; AAF41994; NMB1645.
DR   KEGG; nme:NMB1645; -.
DR   PATRIC; fig|122586.8.peg.2117; -.
DR   HOGENOM; CLU_044847_0_0_4; -.
DR   OMA; YGFVWET; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR021296; DUF2868.
DR   Pfam; PF11067; DUF2868; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..446
FT                   /note="Uncharacterized membrane protein NMB1645"
FT                   /id="PRO_0000320336"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   446 AA;  50221 MW;  01FDCFEC98E04A6F CRC64;
     MLNPSRKLVE LVRILDEGGF IFSGDPVQAT EALRRVDGST EEKIIRRAEM IDRNRMLRET
     LERVRAGSFW LWVVAATFAF FTGFSVTYLL MDNQGLNFFL VLAGVLGMNT LMLAVWLAML
     FLRVKVGRFF SSPATWFRGK DPVNQAVLRL YADEWRQPSV RWKIGATSHS LWLCTLLGML
     VSVLLLLLVR QYTFNWESTL LSNAASVRAV EMLAWLPSKL GFPVPDARAV IEGRLNGNIA
     DARAWSGLLV GSIACYGILP RLLAWVVCKI LLKTSENGLD LEKPYYQAVI RRWQNKITDA
     DTRRETVSAV SPKIILNDAP KWAVMLETEW QDGEWFEGRL AQEWLDKGVA TNREQVAALE
     TELKQKPAQL LIGVRAQTVP DRGVLRQIVR LSEAAQGGAV VQLLAEQGLS DDLSEKLEHW
     RNALAECGAA WLEPDRAAQE GRLKDQ