ID   Y1649_METJA             Reviewed;         387 AA.
AC   Q59043;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative ribosomal RNA large subunit methyltransferase MJ1649;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MJ1649;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmI family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB99670.1; -; Genomic_DNA.
DR   PIR; G64505; G64505.
DR   AlphaFoldDB; Q59043; -.
DR   SMR; Q59043; -.
DR   STRING; 243232.MJ_1649; -.
DR   EnsemblBacteria; AAB99670; AAB99670; MJ_1649.
DR   KEGG; mja:MJ_1649; -.
DR   eggNOG; arCOG00032; Archaea.
DR   HOGENOM; CLU_014042_0_0_2; -.
DR   InParanoid; Q59043; -.
DR   OMA; VMDVFDY; -.
DR   PhylomeDB; Q59043; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR019614; SAM-dep_methyl-trfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF10672; Methyltrans_SAM; 1.
DR   Pfam; PF01472; PUA; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; RNA-binding;
KW   rRNA processing; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..387
FT                   /note="Putative ribosomal RNA large subunit
FT                   methyltransferase MJ1649"
FT                   /id="PRO_0000213172"
FT   DOMAIN          5..81
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ   SEQUENCE   387 AA;  45222 MW;  7A03FF3C1B6730B6 CRC64;
     MVMILIKLEI DRRAYNSIKN FSRLVYTKAI KNRGDLPKKE EIVTLTYNGK FVAKALYNPK
     SVILKILTTE DEEIDYDFFY KRIFNAKIYR ENILNYKNTY RWIYAEGDEL PTIIFDKYNE
     LGAMQLMSKL IEKEYLKDIV DILFELSDLE TIYVKRGKKG ERIRDKIFGD KNKFETVIKE
     GDAKFKVNVR GHKTGFFLDQ RENRLYLEKF IKEGDRVLDI CCYTGGFSVH AAIRGAEVVG
     VDLSKKALKL AEENIELNNI PKDRYEFIEG NAFEVMKEMI EDKEKFDVVI LDPPAFTQTE
     DDIKNALRAY ASLNYLGIKL AKRIFVTCSC SHHVDKEMFK RTVISSAFRA KKELIMIDYK
     GQAPDHPISI GNKNLEYLKC IFFYVKN