ID   Y165_STAES              Reviewed;         251 AA.
AC   Q8CQE3;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Uncharacterized response regulatory protein SE_0165;
GN   OrderedLocusNames=SE_0165;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Probable member of the two-component regulatory system
CC       SE_0166/SE_0165. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by SE_0166. {ECO:0000305}.
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DR   EMBL; AE015929; AAO03762.1; -; Genomic_DNA.
DR   RefSeq; NP_763720.1; NC_004461.1.
DR   RefSeq; WP_002455962.1; NZ_WBME01000072.1.
DR   AlphaFoldDB; Q8CQE3; -.
DR   SMR; Q8CQE3; -.
DR   STRING; 176280.SE_0165; -.
DR   EnsemblBacteria; AAO03762; AAO03762; SE_0165.
DR   GeneID; 50017573; -.
DR   KEGG; sep:SE_0165; -.
DR   PATRIC; fig|176280.10.peg.151; -.
DR   eggNOG; COG2207; Bacteria.
DR   eggNOG; COG4753; Bacteria.
DR   HOGENOM; CLU_000445_5_1_9; -.
DR   OMA; IMTAFEM; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF12833; HTH_18; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..251
FT                   /note="Uncharacterized response regulatory protein SE_0165"
FT                   /id="PRO_0000299117"
FT   DOMAIN          3..118
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          152..249
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        169..190
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        216..239
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   251 AA;  29903 MW;  6746DD4BEDBB74ED CRC64;
     MFKVVICDDE RIIRQGLKQM IPWKEYHFTT IYTATDGVEA LSLIRQHQPE LVITDIRMPR
     KNGVDLLDDI KDLDCQVIIL SSYDDFEYMK AGIQHHVLDY LLKPVDHTQL EHILDILVQR
     LLERPHSTND DAAYYTAFQP LLKIDYDDYY VNQILSQIKQ HYHKKVTVLD LINPIVVSES
     YAMRTFKEHV GITIVDYLNR YRILKSLHLL DQHYKHYEIA EKVGFSEYKM FCYHFKKYLH
     MSPSDYNKLS K