ID   Y1667_HAEIN             Reviewed;         489 AA.
AC   P44285;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Putative L,D-transpeptidase HI_1667;
DE            EC=2.-.-.-;
GN   OrderedLocusNames=HI_1667;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the YkuD family. {ECO:0000305}.
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DR   EMBL; L42023; AAC23312.1; -; Genomic_DNA.
DR   PIR; G64039; G64039.
DR   RefSeq; NP_439809.1; NC_000907.1.
DR   RefSeq; WP_005694392.1; NC_000907.1.
DR   AlphaFoldDB; P44285; -.
DR   SMR; P44285; -.
DR   STRING; 71421.HI_1667; -.
DR   EnsemblBacteria; AAC23312; AAC23312; HI_1667.
DR   KEGG; hin:HI_1667; -.
DR   PATRIC; fig|71421.8.peg.1745; -.
DR   eggNOG; COG2989; Bacteria.
DR   HOGENOM; CLU_020360_3_0_6; -.
DR   OMA; HNLFQRD; -.
DR   PhylomeDB; P44285; -.
DR   BioCyc; HINF71421:G1GJ1-1683-MON; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0071972; F:peptidoglycan L,D-transpeptidase activity; IEA:UniProt.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   CDD; cd16913; YkuD_like; 1.
DR   Gene3D; 2.40.440.10; -; 1.
DR   InterPro; IPR005490; LD_TPept_cat_dom.
DR   InterPro; IPR045380; LD_TPept_scaffold_dom.
DR   InterPro; IPR038063; Transpep_catalytic_dom.
DR   Pfam; PF20142; Scaffold; 1.
DR   Pfam; PF03734; YkuD; 1.
DR   SUPFAM; SSF141523; SSF141523; 1.
PE   3: Inferred from homology;
KW   Cell shape; Cell wall biogenesis/degradation; Glycosyltransferase;
KW   Hydrolase; Membrane; Peptidoglycan synthesis; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..489
FT                   /note="Putative L,D-transpeptidase HI_1667"
FT                   /id="PRO_0000168767"
FT   TRANSMEM        10..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        403
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   489 AA;  55582 MW;  1276A5C79D7E3A56 CRC64;
     MVVFKSTLKL SLFALSLSMM MSGCVLVGLS KNDQSKSLYG INLSHLSLAE RKELEEAIYA
     DQQRLTEEKQ TLLNMTLTHE IGDHKLQFKP LLARLYASRK YAPLWTDNAA ARQLLRDYAA
     MVASGISKSS ATSLETLALV EQQGGLVYDV LLSDILLDYL YYTQNVRSQA SNWLYSSAQY
     QAQQPENDHI QRWLSAVENN QLLDFIQSLA GENHLYRQTI QSLPMFIPTS KESNITQKLA
     MNAQRLRVIP DFHNGIFVNI PSYKLQYYRD GDLILESRVI VGTNSRRTPV MYSKLSNVVV
     NPPWNAPIRL INEDLLPKMK ADPNYITEHN YSILDNQGNV VDPASIDWES IDNKFPYRVR
     QAAGDSALGN YKFNMPSSDA IYLHDTPNRG LFNRKNRALS SGCVRVEKSD QLASILLKEA
     GWTETRKNTV LASKKTTSAP IRSDNPVFLY YVTAWIENGN IVNLPDIYGY DRQINLAEIN
     WDLVKKYLQ