ID   Y1669_MYCLB             Reviewed;         282 AA.
AC   B8ZS00;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Uncharacterized oxidoreductase MLBr01669;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MLBr01669;
OS   Mycobacterium leprae (strain Br4923).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=561304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Br4923;
RX   PubMed=19881526; DOI=10.1038/ng.477;
RA   Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A.,
RA   Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C.,
RA   Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H.,
RA   Vera-Cabrera L., Stefani M.M., Banu S., Macdonald M., Sapkota B.R.,
RA   Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A.,
RA   Rougemont J., Brennan P.J., Cole S.T.;
RT   "Comparative genomic and phylogeographic analysis of Mycobacterium
RT   leprae.";
RL   Nat. Genet. 41:1282-1289(2009).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FM211192; CAR71764.1; -; Genomic_DNA.
DR   RefSeq; WP_010908468.1; NC_011896.1.
DR   AlphaFoldDB; B8ZS00; -.
DR   SMR; B8ZS00; -.
DR   EnsemblBacteria; CAR71764; CAR71764; MLBr01669.
DR   KEGG; mlb:MLBr01669; -.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   OMA; KLWPTDQ; -.
DR   OrthoDB; 1035565at2; -.
DR   Proteomes; UP000006900; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..282
FT                   /note="Uncharacterized oxidoreductase MLBr01669"
FT                   /id="PRO_0000380736"
FT   ACT_SITE        57
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         115
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         195..247
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  30693 MW;  54D63BBBBE4D120B CRC64;
     MMPSTPRTSI PSITLNDENT MPLLGLGVAE LSEDETERAV LAALEIGCRL IDTAAAYGNE
     AAVSRAIAAS GIPRAQLFVT TKLATPDQGF TKSQDACNAS LDRLGMDYVD LYLIHWPAPP
     VGQYVDAWGG MIQSRGEGHA RSIGVCNFTE EHLSAIIDLT FVTPAVNQIE LHPLLNQDEM
     RKSNAQHNVI TQSYTPLVLG RLMDNSTLTA IAAEYGKTPA QVLLRWNLQL GNAVVFRSAK
     AEHIASNFDV FDFELAVNHM DAMNELHDGT RLRPDPETYA GS