ID   Y1669_MYCLE             Reviewed;         282 AA.
AC   O69462;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Uncharacterized oxidoreductase ML1669;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=ML1669; ORFNames=MLCB1243.03c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; AL023635; CAA19184.1; -; Genomic_DNA.
DR   EMBL; AL583923; CAC30622.1; -; Genomic_DNA.
DR   PIR; T44699; T44699.
DR   RefSeq; NP_302147.1; NC_002677.1.
DR   RefSeq; WP_010908468.1; NC_002677.1.
DR   AlphaFoldDB; O69462; -.
DR   SMR; O69462; -.
DR   STRING; 272631.ML1669; -.
DR   EnsemblBacteria; CAC30622; CAC30622; CAC30622.
DR   KEGG; mle:ML1669; -.
DR   PATRIC; fig|272631.5.peg.3155; -.
DR   Leproma; ML1669; -.
DR   eggNOG; COG0656; Bacteria.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   OMA; KLWPTDQ; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..282
FT                   /note="Uncharacterized oxidoreductase ML1669"
FT                   /id="PRO_0000380735"
FT   ACT_SITE        57
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         115
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         195..247
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  30693 MW;  54D63BBBBE4D120B CRC64;
     MMPSTPRTSI PSITLNDENT MPLLGLGVAE LSEDETERAV LAALEIGCRL IDTAAAYGNE
     AAVSRAIAAS GIPRAQLFVT TKLATPDQGF TKSQDACNAS LDRLGMDYVD LYLIHWPAPP
     VGQYVDAWGG MIQSRGEGHA RSIGVCNFTE EHLSAIIDLT FVTPAVNQIE LHPLLNQDEM
     RKSNAQHNVI TQSYTPLVLG RLMDNSTLTA IAAEYGKTPA QVLLRWNLQL GNAVVFRSAK
     AEHIASNFDV FDFELAVNHM DAMNELHDGT RLRPDPETYA GS